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ADA: ABC goals
A1c = < 7%
Blood Pressure = < 130/80 mm/Hg
7 *P R Health Sci J. 2016 Mar; 31(1): 18–23.
Cholesterol (LDL-C) = < 100 mm/dL
BMI = < 30 kg/m2
ADA Consensus Treatment Algorithm
STEP 1 At diagnosis: Lifestyle + MET
If A1C ≥7%
STEP 2 Tier 1: Well-validated core therapies* OR Tier 2: Less well-validated therapies*
Li
Lifestyle + MET +festyle + MET +
Lifestyle + MET + festyle + MET +
Lifestyle + MET + festyle + MET +
Lifestyle + MET + Li GLP-1 receptor eceptor Li
GLP-1 r
PIO
basal insulin insulin
SFU basal agonistst † † PIO
agoni
Lifestyle + MET + festyle + MET +
Lifestyle + MET + festyle + MET +
MET, metformin Li Li
PIO, pioglitazone
basal
PIO +
SFU, sulfonylurea PIO + SFUSFU basal insulin insulin
STEP 3 Lifestyle + MET + intensive insulin
*Validation based on clinical trials and clinical judgment.
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† Insufficient clinical use to be confident regarding safety.
Adapted from Nathan DM, et al. Diabetes Care. 2009.
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