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4/11/2019

































                                                          ADA: ABC goals
                                                            A1c = < 7%
                                                     Blood Pressure = < 130/80 mm/Hg
                                7  *P R Health Sci J. 2016 Mar; 31(1): 18–23.
                                                    Cholesterol (LDL-C) =  < 100 mm/dL
                                                          BMI = < 30 kg/m2











                             ADA Consensus Treatment Algorithm




                            STEP 1                  At diagnosis: Lifestyle + MET
                                                             If A1C ≥7%

                            STEP 2  Tier 1: Well-validated core therapies*  OR  Tier 2: Less well-validated therapies*

                                                                    Li
                                                                    Lifestyle + MET +festyle + MET +
                                                                                    Lifestyle + MET + festyle + MET +
                                                    Lifestyle + MET + festyle + MET +
                                    Lifestyle + MET +   Li           GLP-1 receptor eceptor   Li
                                                                     GLP-1 r
                                                                                        PIO
                                                     basal insulin insulin
                                        SFU          basal             agonistst † †    PIO
                                                                       agoni
                                                                    Lifestyle + MET + festyle + MET +
                                                                                    Lifestyle + MET + festyle + MET +
                            MET, metformin                          Li              Li
                            PIO, pioglitazone
                                                                                      basal
                                                                      PIO +
                            SFU, sulfonylurea                         PIO + SFUSFU    basal insulin insulin
                            STEP 3                Lifestyle + MET + intensive insulin
                           *Validation based on clinical trials and clinical judgment.
                               4/11/2019
                           † Insufficient clinical use to be confident regarding safety.
                            Adapted from Nathan DM, et al. Diabetes Care. 2009.

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