Page 4 - Pharma GIT L1

 Anticholinergic drugs ( atropine) antagonize its Prokinetic action.

 Other dopamine antagonists (antipsychotic drugs) administered with

metoclopramide may precipitate acute extrapyramidal reactions.

 Domperidone.



 It blocks Peripheral D2 receptors (because it does NOT cross BBB)

leading to:

 Decrease the inhibitory action of dopamine on the GIT motility.

 No CNS side effects.

 Antiemetic effect: less than metoclopramide.

 There is growing evidence that Domperidone may ↑ QT interval and

predispose to serious arrhythmia and sudden death.