Page 8 - Pharma GIT L1

4. 5HT3 antagonists:  They block 5HT3  Headache.

 Ondansetron. receptors in CTZ.  GIT upsets.

 Granisetron.

 Dolasetron.

 All are equivalent in efficacy, adverse effects, convenience & cost.

 Very effective in controlling acute nausea & vomiting associated with ordinary dose chemotherapy.

 Less effective in controlling delayed emesis & that due to high dose cancer chemotherapy.

 Used in Vomiting caused by cytotoxic drugs (Ondansetron is the drug of first choice).

5. Neurokinin (NK1)  Used for prevention

receptor blocker: of acute & delayed

 Aprepitant. vomiting associated

---- with highly ---

emetogenic cancer

chemotherapy.

6. Tetrahydrocannabinol:  Marijuana derivative.  General CNS

 Nabilone.  Cannabinoid receptors disturbances.

agonist.  Anti-parasympathetic

effects.

 Drowsiness.