Page 4 - C.Journal 3rd edition
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Claims Journal 3rd Edition Claims Journal 3rd Edition
Cymbalta
O.P.L
Prepared by Sundos Basudan
Use and Dose Adverse reactions Contraindications
Cymbalta (duloxetine) is a selective serotonin and nor- -Major Depressive Disorder constipation,diarrhea, - The use of MAOIs with
epinephrine reuptake inhibitor antidepressant (SSNRI). -Generalized Anxiety Disorder dizziness, drowsiness, fatigue, Cymbalta or within 5 days
-Diabetic Peripheral hypersomnia, insomnia, of stopping treatment with
Neuropathy nausea, sedation, headache, Cymbalta is contraindicated
Coverage -Fibromyalgia and xerostomia. because of an increased risk
- Cymbalta is covered only in acute cases of depressive -Chronic Musculoskeletal Pain of serotonin syndrome.
disorder and anxiety disorder. - The use of Cymbalta within
14 days of stopping an MAOI
- Cymbalta is approved by SFDA for For adult— Starting dose is 30 intended to treat psychiatric
diabetic neuropathic pain if it is prescribed by neurolo- mg for one week, then increase disorders is also contraindi-
gist or endocrinologist only. to 60 mg once daily. cated
For Children, Adolescents and
Elderly — Initiate Cymbalta at Use in specific populations
a dose of 30 mg once daily for - Cymbalta should not be used during pregnancy
2 weeks before increase to the unless the benefit outweighs the risk to the
target dose of 60 mg. fetus
FDA pregnancy category: C
- Cymbalta is not recommended in breastfeeding
because it’s excreted into human milk.
If used, the infant should be monitored for
drowsiness, adequate weight gain, and develop-
mental milestones
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