Page 7 - GDG676 Handbook
P. 7

The Reaction



         Allergen exposure

                                                           Antigen




         Plasma cells
         produce igE                                        Plasma cell
         antibodies against
         the allergen
                                                            IgE




         IgE antibodies                                    Mast cell with fixed
         attach to mast                                    igE antibodies
         cells and baso-
         phils
                                                           Granules containing
                                                           histamine




         More of same
         allergen enters                                    Allergen
         the body





                                                           Mast cell granules
                                                           release contents
                                                           after antigen binds
                                                           with igE antibodies



                                                           Histamines and other
                                                           mediators
                                          3
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