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small punctate lesions on her lenses bilaterally that   Plunkett, S.J. (2013) Emergency Procedures for the Small
             were consistent with chronic hypocalcemia.     Animal Practitioner, 3rd edn. Saunders Elsevier,
  VetBooks.ir  9.7–12.3  mg/dL).  An ionized calcium (iCa) on a
                                                            Philadelphia, Pennsylvania, USA.
               Her total calcium was low (5.8  mg/dL, normal
             bedside monitor revealed 0.48  mmol/L (normal
             1.2–1.3 mmol/L) with all other electrolytes normal   Bibliography
             or  near normal  including the  sodium  reported by
             her primary care veterinarian (Na= 131  mEq/L;   Bleul, U., Gotz, E. (2014) Evaluation of the i-STAT port-
                                                            able point-of-care analyzer for determination of blood
             normal 139-150  mEq/L).  An electrocardiogram   gases and acid-base status in newborn calves. Journal
             (ECG) placed at the time of presentation revealed a   of  Veterinary Emergency and Critical Care 24,
             variety of  heart  rates and  rhythms ranging  from   519–528.
             sinus bradycardia (heart rate 50–60 bpm) to an   Burnett, R.W., Covington, A.K., Fogh-Andersen, N., et al.
               idioventricular rhythm (heart rate 90–100  bpm)   (2000) Use of ion-selective electrodes for blood-
             and then an escape rhythm (heart rate <40 bpm).   electrolyte  analysis.  Recommendations  for  nomen-
             During the period when she was displaying various   clature, definitions, and conventions. International
             bradyarrhythmias, her measured blood pressure   Federation of Clinical Chemistry and Laboratory
             was 240 mmHg. She was given 1 mL/kg of 10%     Medicine (IFCC). Scientific Division Working Group
             calcium gluconate IV slowly over 30 minutes to   on Selective Electrodes.  Clinical Chemistry and
                                                            Laboratory Medicine 38, 363–70.
             address her hypocalcemia while observing the ECG   Dalal, B.I., Brigden, M.L. (2009) Factitious biochemical
             for worsening bradycardia. She was also given man-  measurements resulting from hematologic condi-
             nitol (1 g/kg IV over 30 minutes) to treat a possible   tions.  American Journal of Clinical Pathology 131,
             Cushing’s reflex (obtunded mentation with brady-  195–204.
             cardia and hypertension).  These signs seemed to   DiBartola, S.P. (2012) Disorders of sodium and water:
             resolve with treatment but it was unclear if the cal-  hypernatremia and hyponatremia. In: Dibartola, S.P.
             cium gluconate or the mannitol had a greater effect.  (ed.)  Fluid, Electrolyte and Acid-Base Disorders in
               Table 8.8 shows Queenie’s serial iCa measure-  Small Animal Practice, 4th edn. Elsevier, St. Louis,
             ments and the intervention taken in response to   Missouri, USA, pp. 45–79.
             each one.  This table is not meant as a guide to   DiBartola, S.P., de Morais, H.A. (2012) Disorders
                                                            of  potassium:  hypokalemia  and  hyperkalemia.
             treatment but simply to illustrate alterations in   In: Dibartola, S.P. (ed.)  Fluid, Electrolyte and
             calcium in response to various interventions in a   Acid-Base Disorders in Small Animal Practice,
             real clinical case.                            4th edn. Elsevier, St. Louis, Missouri, USA, pp.
               Queenie was worked up for her hypocalcemia   92–119.
             and diagnosed with primary hypoparathyroidism   DiBartola, S.P.,  Willard, M.D. (2012) Disorders of
             on the basis of an inappropriately low parathy-  phosphorus: hypophosphatemia and hyperphos-
             roid hormone level (0.6  pmol/L; normal 0.5–   phatemia. In: Dibartola, S.P. (ed.) Fluid, Electrolyte
             5.8 pmol/L) in the face of a low iCa (0.86 mmol/L;   and Acid-Base Disorders in Small Animal Practice,
             normal 1.25–1.45 mmol/L). She was discharged   4th edn. Elsevier, St. Louis, Missouri, USA, pp.
                                                            195–211.
             3 days after presentation on oral calcium carbon-  Estridge, B.H., Reynolds, A.P. (2012) Principles of chem-
             ate tablets and vitamin D to manage her hypopar-  istry instrumentation. In: Estridge, B.H., Reynolds,
             athyroidism. Follow-up 4 months after discharge   A.P. (eds) Basic Clinical Laboratory Techniques, 6th
             revealed that Queenie was doing well aside from   edn. Delmar Cengage Learning, Clifton Park, New
             intermittent  episodes  once  or  twice  a  week   York, USA, pp. 622–629.
             wherein she would run in circles chasing her tail   Higgins, C. (2007) Pseudohyponatremia.  Available at:
             and then freeze, but was responsive to her name   https://acutecaretesting.org/en/articles/pseudohy-
             during those events. Her mentation was back to   ponatremia (accessed 1 March, 2019).
             normal and she was otherwise doing well.    Learn more about flame photometry (2019) Available
                                                            at:  www.sciencedirect.com/topics/medicine-and-
                                                            dentistry/flame-photometry (accessed 15 February
             Further Reading                                2019).
                                                         Liamis, G., Liberopoulos, E., Barkasa, F.,  et al. (2013)
             Matthews, K.M. (2017)  Veterinary Emergency and   Spurious electrolyte disorders: a diagnostic challenge
               Critical Care Manual, 3rd edn. Lifelearn, Guelph,   for  clinicians.  American  Journal  of  Nephrology  38,
               Ontario, Canada.                             50–57.


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