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Brucellosis  138.e3


           Recommended Monitoring              iodinated contrast agents for the documentation   ADDITIONAL SUGGESTED
           •  Clinical signs                   of bronchoesophageal fistulas has been discour-  READINGS
  VetBooks.ir  tion of pneumonia               adverse effects (cough, pulmonary edema).  Veterinary surgery: small animal, ed 2, St. Louis,   Diseases and   Disorders
                                               aged because of the potential for more local
           •  Thoracic radiographs for radiographic resolu-
                                                                                  Monnet E: Lungs. In Johnston SA, et al, editors:
             ○   Treating for 7-10 days beyond radiographic
                                                                                   2018, Elsevier, p 1752-1768.
                                               Prevention
               resolution of pneumonia is commonly
                                                                                   Literature  survey,  case  presentations,  and  radio-
               recommended because radiographic resolu-  •  Limit opportunities for foreign body inges-  Park RD: Bronchoesophageal fistula in the dog:
               tion often lags behind clinical resolution.  tion, particularly in small-breed dogs.  graphic  manifestations.  Compend  Contin  Educ
                                                                                   Vet 6:669-677, 1984.
                                               •  There are no means of preventing a congenital   Spielman BL, et al: Esophageal foreign body in dogs:
            PROGNOSIS & OUTCOME                 bronchoesophageal fistula, but affected dogs   a retrospective study of 23 cases. J Am Anim Hosp
                                                probably should not be bred.       Assoc 28:570-574, 1992.
           A good prognosis is expected if respiratory
           complications are not serious. For patients with   Technician Tips     RELATED CLIENT EDUCATION
           severe respiratory complications, the prognosis   The  presence  of  an  esophageal  foreign  body
           is guarded.                         poses risks of aspiration pneumonia, including   SHEETS
                                               during contrast studies. Changes in respiratory   Consent to Perform Bronchoalveolar Lavage
            PEARLS & CONSIDERATIONS            rate or character could signal an aspiration   (BAL)
                                               event.
           Comments                                                               Consent to Perform Endoscopy, Upper GI
                                                                                    (Gastroduodenoscopy)
           Administration of a dilute concentration of   SUGGESTED READING        Pneumonia
           barium sulfate (20%-30% weight/volume) for   Della Ripa MA, et al: Canine bronchoesophageal
           an esophagram can facilitate demonstration of   fistulas: case report and literature review. Compend   AUTHOR: Rance K. Sellon, DVM, PhD, DACVIM
           a bronchoesophageal fistula. The use of oral   Contin Educ Vet 32:E1-E10, 2010.  EDITOR: Megan Grobman, DVM, MS, DACVIM


            Brucellosis                                                                            Client Education
                                                                                                          Sheet


            BASIC INFORMATION                   pathogenicity may be related to expression   PHYSICAL EXAM FINDINGS
                                                of a specific fatty acid (19 : 0 cyclopropane   As for History above. Additional manifestations
           Definition                           [lactobacillic acid], w8c [cis-11,12-methylene   of systemic disease in various organs (e.g., bone,
           Infection with gram-negative intracellular   octadecanoic acid]) in some strains of B. canis.  eyes, brain): lymphadenopathy, splenomegaly,
           coccobacillus or rod-shaped bacteria, Brucella                         blepharospasm, and ocular changes (recurrent
           canis (most commonly) or, less commonly in   GEOGRAPHY AND SEASONALITY  anterior uveitis), lameness, or paraspinal pain
           dogs, Brucella abortus, Brucella suis, or Brucella   Worldwide  distribution:  endemic  in  the   with paresis or paralysis (discospondylitis)
           melitensis                          southern United States and in Central and
                                               South America, sporadic elsewhere  Etiology and Pathophysiology
           Epidemiology                                                           •  Bacteria  penetrate  exposed  mucous  mem-
           SPECIES, AGE, SEX                   ASSOCIATED DISORDERS                 branes of oral cavity, conjunctiva, nasal tissue,
           Any dog; no sex predisposition but sexually   Discospondylitis, anterior uveitis (end-  penis, or vaginal vault.
           intact status increases incidence (venereal   ophthalmitis), reproductive failure and disease   •  Organisms shed through highly contaminated
           transmission)                       (see below)                          vaginal discharge, milk of lactating bitch,
                                                                                    semen, prostatic fluid, vaginal fluid during
           RISK FACTORS                        Clinical Presentation                estrus, and lochia of parturition. After abor-
           Housing or breeding with infected animals  HISTORY, CHIEF COMPLAINT      tion, females may continue to shed bacteria
                                               Female:                              intermittently for weeks or months.
           CONTAGION AND ZOONOSIS              •  Failure to conceive, early embryonic death,   •  Urine has been suggested as the most impor-
           •  Sources of B. canis organisms include vaginal   fetal resorption      tant source of infection: bacteria are at the
             and preputial discharge, aborted tissue, semen   •  Abortion at 45-55 days of gestation, possibly   highest concentration in urine 1-6 months
             (including frozen semen), milk, urine, and   with no other signs       after infection and before overt clinical signs.
             to a lesser extent, salivary and nasal secre-  •  Birth of stillborn, partially autolyzed, or weak   ○   Culture in rough or mucoid phase on
             tions.  Transmission occurs between naive   pups                         primary isolation. However, culture is
             and infected dogs.                •  Persistent, highly infective mucopurulent or   time-consuming and fastidious because
           •  Reportable  zoonosis  in  some  U.S.  states  if   serosanguineous vulvar discharge for 1-6   Brucella organisms do not grow easily in
             confirmatory tests are positive. Human cases   weeks postpartum          culture.
             rare but possible from close physical contact   •  Recurrent abortions followed by a normal   •  Phagocytized, B. canis remains viable intracel-
             with infected dog, especially if the human is   whelping of live or dead pups  lularly in regional and other lymph nodes
             young, pregnant, or immunocompromised.   Male:                         and blood for months to years. Bacteremia
             Seroprevalence studies have shown that   •  Orchitis (scrotal swelling, testicular atrophy   within  1-4 weeks after  infection;  episodic
             women are at a greater risk than men.   in chronic infections)         for months to more than 5 years
             Because of their exposure to dogs and a   •  Epididymitis            •  Clinical signs of reproductive tract disease in
             more concentrated contact with sick dogs   •  Poor semen quality (as many as 90% of sperm   bitches due to placentitis and metritis and, in
             than the general population, the prevalence   may be abnormal)         male dogs, due to epididymal inflammation
             of B. canis antibodies among the practicing   •  Prostatitis           and subsequent autoimmune destruction of
             veterinarians in one study was 72.6%. Human   •  Decreased libido      testicular tissue

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