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Histiocytic Diseases   473


                                                                                    ○   Limited activity for 1 month
                                                                                    ○   Radiography after sling application and
  VetBooks.ir                                                                     •  For open repairs                 Diseases and   Disorders
                                                                                      if lameness recurs
                                                                                    ○   Restricted ambulation for 1-2 months
                                                                                    ○   Radiography if lameness recurs and based
                                                                                      on fixation method
                                                                                   PROGNOSIS & OUTCOME

                                                                                  •  Variable  with  closed  reduction:  50%  fail
                                                                                    due to technical error or unrecognized joint
                                                                                    disease
                                                                                  •  Good  to  excellent  with  most  operative
                                                                                    procedures of acute injuries (i.e., previously
                                                                                    normal joint)
           HIP LUXATION  Postoperative ventrodorsal projection of hip joints of an obese 45-kg dog treated for traumatic   •  Guarded  for  dysplastic  hips  unless  TPO,
           bilateral hip luxation. Bilateral toggle pins and greater trochanter–to–ilium wires were used for stabilizing injuries.   FHNE, THR performed
               and  rectus  femoris  muscle,  iliofemoral   •  Nonsteroidal  anti-inflammatory  drugs    PEARLS & CONSIDERATIONS
               suture, synthetic sutures to replace capsule,   (NSAIDs) as needed to reduce pain and
               gluteal muscle tenodesis         inflammation                      Comments
             ○   Intraarticular techniques: toggle pinning,   ○   Carprofen 2 mg/kg PO q 12h (dogs), or  •  With normal hips, reduction/stabilization is
               fascia lata loop or sacrotuberous ligament   ○   Deracoxib 1-2 mg/kg PO q 24h (dogs;   preferred over FHNE for all patient sizes.
               transposition                      may use 3-4 mg/kg PO q 24h for first 7   •  Extensive joint capsule and ligament damage
           •  Triple  or  double  pelvic  osteotomy  can   days only), or           impede successful closed reduction.
             be performed for mildly dysplastic,   ○   Meloxicam 0.1 mg/kg (dogs), 0.05 mg/  •  Femoral head ligament avulsion fractures are
             immature dogs with no degenerative joint     kg (cats) PO q 24h, or    often not recognized radiographically.
             changes.                           ○   Firocoxib 5 mg/kg PO q 24h (dogs)
           •  For chronic injuries, open reduction is dif-                        Technician Tips
             ficult because of muscular contraction and   Possible Complications  Ehmer slings require frequent monitoring for
             tissue fibrosis; cartilage degeneration exists.   •  Reluxation      pes ischemia or wounds beneath the tape.
             FHNE or THR may be required in place   •  Implant failure
             of primary repairs.               •  Degenerative joint disease      SUGGESTED READING
                                               •  Infection                       Wardlaw JL, et al: Coxofemoral luxation. In Tobias
           Chronic Treatment                                                       KM, et al, editors: Veterinary surgery: small animal,
           •  Physical rehabilitation to maintain muscle   Recommended Monitoring  ed 2, St. Louis, 2018, Elsevier, pp 956-964.
             tone, joint health, and overall limb functions  •  For closed reduction  AUTHOR: Joseph Harari, DVM, MS, DACVS
           •  Controlled  activity  to  avoid  reluxation,   ○   Frequent sling evaluations and removal   EDITOR: Kathleen Linn, DVM, MS, DACVS
             implant failures                     7-10 days after application




            Histiocytic Diseases                                                                   Client Education
                                                                                                         Sheet


            BASIC INFORMATION                   ○   Cutaneous Langerhans cell histiocytosis   ○   Malignant fibrous histiocytoma: despite
                                                  (LCH) includes multiple skin lesions that   its name, this focal lesion is a unique soft-
           Definition                             resemble histiocytomas and can involve   tissue sarcoma and is not discussed here.
           A complex group of syndromes resulting from   lymph nodes.                 The histiocytic infiltrate is not neoplastic
           an accumulation of histiocytes, which include   •  Reactive histiocytic disorders (from activated   and is of questionable importance.
           cells of macrophage or dendritic origin and   DCs, dogs only)
           function as antigen-presenting cells. Clinical   ○   Cutaneous histiocytosis (CH): a benign   Synonyms
           and histologic characteristics are needed to   accumulation of histiocytes in the skin   Histiocytic sarcoma (disseminated): malignant
           distinguish tumors and syndromes. Most   with predisposition for the nasal planum,   histiocytosis
           arise from dendritic cells (DCs), specifically   head, and neck        Epidemiology
           interstitial DCs, and less commonly from   ○   Systemic  histiocytosis  (SH):  similar  to
           Langerhans DCs (in the epidermis). Histiocytic   cutaneous histiocytosis but characterized   SPECIES, AGE, SEX
           diseases occur in dogs and cats, although reports   by lymph node and organ involvement  •  Histiocytic diseases have predominantly been
           in cats are sparse and are limited to malignant   •  Malignant  histiocytic  neoplasia  (from   reported for dogs, but reports exist for cats
           neoplasia. Histiocytic disorders can be simplified   interstitial DCs)   (malignant histiocytosis).
           into the following groups:           ○   Histiocytic sarcoma (HS): focal or dissemi-  •  Cutaneous histiocytosis can occur in younger
           •  Benign tumors                       nated; the latter is commonly considered   dogs, compared with systemic histiocytosis
             ○   Histiocytoma: spontaneously regressing   synonymous with malignant histiocytosis.  and disseminated HS in middle-aged dogs
               skin tumor of Langerhans cells common   ○   Hemophagocytic  histiocytic  sarcoma   (median age, 6 years).
               in young animals                   originates from macrophages.    •  Equal prevalence in males and females

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