Page 182 - BSAVA Guide to Pain Management in Small Animal Practice
P. 182

7   |  Pain in birds



        VetBooks.ir  Drug  Notes*                            Dose     Author
                                                             range in
                                                                      recommendations
                                                                      and guidance
                                                             literature*
             Opioids continued
              ramadol   •  Provides analgesia by opioid  mu , serotonin and             1  mg kg orally every
                         norepinephrine pathways with minimal adverse   mg kg   8 1 h in birds of prey
                         e ects                              orally   and every 6 8h in
                        •  It is a potent oral analgesic that is not currently under    4 6h  parrots
                         tight medication regulations                  he dose may need to
                        •  E ective doses reported include   mg kg orally  1 h   be higher in parrots but
                         in bald eagles,   mg kg i.v. in  ispaniolan Ama on   this dose appears to
                         parrots, 11 mg kg orally for 4h in red tailed hawks   have some e ect
                         and    mg kg orally for 6h in  ispaniolan Ama on   anecdotally.  ore data
                         parrots  where 1  and    mg kg were ine ective   re uired
                        •  In American kestrels,   mg kg orally was only
                         e ective for 1.  hours
              ydro      •  Semi synthetic mu receptor agonist   .1  .6   Never been used by this
             morphone   •    4 times more potent than morphine   mg kg  6h  author
                        •   hen evaluated at  .1,  .  and  .6 mg kg, showed a   Refer to literature dose
                         dose dependent response when given to American
                         kestrels but only sedation when given to cockatiels
             NSAIDs
              etoprofen  •   igh bioavailability orally in mammals, but limited          Not recommended due
                         oral P  data in birds. Lack of convenient oral   mg kg  to potential renal e ects
                         formulations mean it is used mainly parenterally
                        •      mg kg resulted in deaths of male eiders  may be
                         related to behaviour leading to dehydration
                        •    mg kg in mallards appeared e ective for 1 h
                        •   .  mg kg   4h for 7d caused renal tubular necrosis
                         in budgies.
              eloxicam  •   ost widely used NSAI  in avian medicine   .1       .  1 mg kg i.m.   4h  or
                        •  Convenient to use as in ectable and oral formulations   mg kg   1 h  and 1.    mg kg
                         in two di erent strengths                    orally   4h  or  1 h
                        •  Survey to determine NSAI  toxicity in captive birds   Anecdotally, once daily
                         treated in  oos reported  ero fatalities associated   dosing appears e ective
                         with meloxicam  7   birds from 6  species    to this author but P  and
                        •  P  studies in multiple avian species       P  data in the literature
                        •  1 mg kg of meloxicam i.m.  1 h in  ispaniolan   do not always support
                         Ama on parrots was necessary to achieve analgesia   this.  here is evidence
                          lower bioavailability orally                that the anti
                        •  1.6 mg kg  1 h orally for 1 d in parrots and   mg kg   in ammatory and
                         i.m.   4h for 14d in  uail had no adverse e ects   analgesic e ects of
                        •  1 mg kg i.m. for 7d was e ective in African grey   NSAI s continue longer
                         parrots                                      than predicted by
                        •  In pigeons,   mg kg orally  1 h was e ective but  .    plasma half lives
                         mg kg was not                                Avoid if hypoperfusion is
                        •   espite meloxicam s large therapeutic range and   likely  dehydration or
                         relative safety compared with other NSAI s, adverse   anaesthesia
                         e ects in di erent species should continue to be
                         evaluated
                     continued  Analgesia drugs used in birds.  Information referenced from  awkins et al.,   16.
                3   CRI   continuous rate infusion;  AC   mean anaesthetic concentration; NSAI    non steroidal anti
             in ammatory drug; P    pharmacodynamic; P    pharmacokinetic.  continues

                                                                                    177



         Ch07J Pain Management.indd   177                                       19/12/2018   10:47
   177   178   179   180   181   182   183   184   185   186   187