Page 1282 - Veterinary Immunology, 10th Edition

Cruciate Ligament Rupture
VetBooks.ir While genetic/structural causes predominate, immunological

abnormalities are also associated with spontaneous rupture of the

anterior cruciate ligament in dogs. For example, the synovia of
affected dogs contains B cells, IgG-positive plasma cells, and
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numerous MHC class II , CD1c dendritic cells. Thus it resembles
the lesions seen in rheumatoid arthritis. Cruciate ligaments are
mainly composed of type I collagen. Autoantibodies to both type I
and type II collagen are found in synovial fluid following cruciate
ligament rupture (secondary to osteoarthritis), usually bound in
immune complexes. They are probably secondary to tissue damage.

CXCL8 (IL-8) levels rise in joints before cruciate ligament rupture,
implying that inflammation precedes rupture.

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