Page 1384 - Veterinary Immunology, 10th Edition

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FIG. 41.6 Some of the many postulated activities mediated by
intravenous immunoglobulins (IVIG). In addition, the sialyl groups
bind to SIGN and trigger immunomodulatory pathways.

When administered to dogs, IVIG causes a mild

thrombocytopenia, leucopenia, increased total plasma protein,
increases in fibrin degradation products, thrombin-antithrombin
complexes, and C-reactive protein. In effect it enhances blood

coagulation and some inflammatory responses. It also binds to
+
+
canine monocytes and lymphocytes (CD4 T, CD8 T, and B) and
inhibits antibody-mediated phagocytosis by monocytes. IVIG has
been used to successfully treat immune-mediated hemolytic
anemia, thrombocytopenia, and pemphigus, as well as severe

cutaneous drug reactions such as erythema multiforme and
Stevens-Johnson syndrome (Chapter 33). Most authors report
positive clinical responses with minimal adverse reactions.

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