Page 1545 - Saunders Comprehensive Review For NCLEX-RN

5. Causes diarrhea and abdominal pain

6. Contraindicated for use in pregnancy

B. Sucralfate
1. Creates a protective barrier against acid and pepsin
2. Administered orally; should be taken on an

empty stomach
3. May cause constipation

4. May impede absorption of warfarin sodium,

phenytoin, theophylline, digoxin, and some
antibiotics; should be administered at least 2 hours
apart from these medications
III. Histamine (H )-Receptor Antagonists
2
A. Description
1. Suppress secretion of gastric acid
2. Alleviate symptoms of heartburn and assist in
preventing complications of peptic ulcer disease
3. Prevent stress ulcers and reduce the recurrence of all
ulcers
4. Promote healing in gastroesophageal reflux disease
5. Are contraindicated in hypersensitive clients
6. Should be used with caution in clients with

impaired renal or hepatic function
B. Cimetidine
1. Can be administered orally, intramuscularly, or
intravenously

2. Food reduces the rate of absorption; if taken

orally with meals, absorption will be slowed.
3. Intravenous administration can cause hypotension
and dysrhythmias.

4. Antacids can decrease the absorption of oral

cimetidine.

5. Cimetidine and antacids should be

administered at least 1 hour apart from each other.
6. Cimetidine passes the blood–brain barrier, and central
nervous system side and adverse effects can occur; it
may cause mental confusion, agitation, psychosis,

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