Page 2204 - Saunders Comprehensive Review For NCLEX-RN

acidosis, and severe hepatomegaly
5. Emtricitabine/tenofovir: In addition to the effects that
can occur from emtricitabine and tenofovir (see later),
lactic acidosis and severe hepatomegaly can occur.
6. Lamivudine: Causes nausea and nasal congestion
7. Lamivudine/zidovudine: Can cause anemia and
neutropenia and lactic acidosis with hepatomegaly
8. Lamivudine/zidovudine/abacavir: In addition to the
effects that can occur from lamivudine, zidovudine
(see later), and abacavir, hypersensitivity reactions,
anemia, neutropenia, lactic acidosis, and severe
hepatomegaly can occur.
9. Stavudine: Can cause peripheral neuropathy and
pancreatitis
10. Tenofovir: Can cause nausea and vomiting
11. Zidovudine: Can cause nausea, vomiting, anemia,
leukopenia, myopathy, fatigue, and headache

H. Nonnucleoside reverse transcriptase inhibitors (NNRTIs)

1. Delavirdine: Can cause rash, liver function changes,
and pruritus
2. Efavirenz: Can cause rash, dizziness, confusion,
difficulty concentrating, dreams, and encephalopathy
3. Etravirine: Can cause rash, gastrointestinal
disturbances, headache, hypertension, and peripheral
neuropathy
4. Nevirapine: Can cause rash, Stevens-Johnson
syndrome, hepatitis, and increased transaminase
levels
5. Rilpivirine can cause headache, nausea, stomach pain,
rash, dizziness, and feeling sleepy during the
daytime.

I. Protease inhibitors (PIs)

1. Atazanavir: Can cause nausea, headache, infection,
vomiting, diarrhea, drowsiness, insomnia, fever,
hyperglycemia, hyperlipidemia, and increased
bleeding in clients with hemophilia
2. Darunavir: Can cause diarrhea, nausea, vomiting,
heartburn, stomach pain, headache, rash, changes in
the shape and location of body fat
3. Fosamprenavir: Can cause nausea, vomiting,
headache, altered taste sensations, perioral
paresthesia, rashes, and altered liver function
4. Indinavir: Can cause nausea, diarrhea,
hyperbilirubinemia, nephritis, and kidney stones
5. Lopinavir/ritonavir: Can cause nausea, diarrhea,

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