Page 2206 - Saunders Comprehensive Review For NCLEX-RN

autoimmune disorders such as systemic lupus erythematosus.
B. Cyclosporine
1. Used for prevention of rejection following allogeneic
organ transplantation
2. Usually administered with a glucocorticoid and
another immunosuppressant
3. The most common adverse effects are nephrotoxicity,
infection, hypertension, and hirsutism.
C. Tacrolimus
1. Used for prevention of rejection following liver or
kidney transplantation
2. Adverse effects include nephrotoxicity, neurotoxicity,
gastrointestinal effects, hypertension, hyperkalemia,
hyperglycemia, hirsutism, and gum hyperplasia.
D. Azathioprine
1. Generally used with renal transplant recipients
2. Can cause neutropenia and thrombocytopenia
E. Cyclophosphamide
1. Used for its immunosuppressant action to treat
autoimmune disorders
2. Can cause neutropenia and hemorrhagic cystitis
F. Methotrexate
1. Used for its immunosuppressant action to treat
autoimmune disorders
2. Can cause hepatic fibrosis and cirrhosis, bone marrow
suppression, ulcerative stomatitis, and renal damage
G. Mycophenolate mofetil and mycophenolic acid
1. Used to prevent rejection following kidney, heart, and
liver transplantation
2. Can cause diarrhea, vomiting, neutropenia, and sepsis;
increases the risk of infection and malignancies,
especially lymphomas
H. Basiliximab
1. Used to prevent rejection following kidney
transplantation
2. Can cause severe acute hypersensitivity reactions,
including anaphylaxis
I. Lymphocyte immune globulin, antithymocyte globulin,
muromonab CD3
1. Used to prevent rejection following kidney, heart,
liver, and bone marrow transplantation
2. Side and adverse effects include fever, chills,
leukopenia, and skin reactions.
3. Can cause anaphylactoid reactions
J. Sirolimus
1. Used to prevent renal transplant rejection
2. Increases the risk of infection; raises cholesterol and
triglyceride levels; can cause renal injury

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