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an anaphylactic reaction to a previously administered
                                                vaccine or a component in the vaccine.
                                             2. Live virus vaccines generally are not administered to
                                                individuals with severely deficient immune systems,
                                                individuals with a severe sensitivity to gelatin, or
                                                pregnant women.
                                             3. A vaccine is administered with caution to an
                                                individual with a moderate or severe acute illness,
                                                with or without fever.
                                             4. See Section IX, Recommended Childhood and
                                                Adolescent Immunizations, for specific information
                                                for each type of vaccine.
                                C. Guidelines for administration (Box 18-4)



                                          Children born preterm should receive the full dose of each vaccine at the


                                   appropriate chronological age.
                    IX. Recommended Childhood and Adolescent Immunizations (Box 18-5)
                                A. For the most up-to-date information, refer to Centers for Disease
                                   Control and Prevention (CDC) Web site:
                                   http://www.cdc.gov/vaccines/schedules/index.html.
                                B. Hepatitis B vaccine (HepB)
                                             1. Administered by the intramuscular route
                                             2. Contraindications: Severe allergic reaction to previous
                                                dose or vaccine component (components include
                                                aluminum hydroxide, yeast protein)
                                             3. Precautions: An infant weighing less than 2000 g or an
                                                infant with moderate or severe acute illness with or
                                                without fever
                                             4. HBsAg (hepatitis B surface antigen)-positive mothers
                                                             a. Infant should receive HepB vaccine and
                                                                hepatitis B immunoglobulin (HBIG)
                                                                within 12 hours of birth.
                                                             b. Infant should be tested for HBsAg and
                                                                antibody to HBsAg after completion of
                                                                HepB series (9 to 18 months of age).
                                             5. Mother whose HBsAg status is unknown
                                                             a. Infant should receive the first dose of
                                                                hepatitis vaccine series within 12 hours
                                                                of birth.
                                                             b. Maternal blood should be drawn as
                                                                soon as possible to determine the
                                                                mother’s HBsAg status.
                                                             c. If the mother’s HBsAg test result is
                                                                positive, the infant should receive
                                                                HBIG as soon as possible (no later than
                                                                1 week of age).




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