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A28    SCIENCE
             Wednesday 4 september 2019
            How much pot in that brownie? Chocolate can throw off tests




                                                                                                                                arating  into  unappealing
                                                                                                                                layers  while  sitting  on  the
                                                                                                                                shelf. The oils don’t dissolve
                                                                                                                                in  water,  a  problem  for
                                                                                                                                companies trying to create
                                                                                                                                new drinks.
                                                                                                                                “We’re fighting against the
                                                                                                                                true  nature  of  the  THC,”
                                                                                                                                Vialpando,  who  came  to
                                                                                                                                cannabis  from  the  phar-
                                                                                                                                maceutical industry.
                                                                                                                                Chemists solve the problem
                                                                                                                                by  increasing  the  surface
                                                                                                                                area of the oil particles and
                                                                                                                                adding  ingredients,  called
                                                                                                                                surfactants and emulsifiers,
                                                                                                                                to prevent separation.
                                                                                                                                She said consumers should
                                                                                                                                be skeptical of outrageous
                                                                                                                                claims for edibles and bev-
                                                                                                                                erages,  including  that  all
                                                                                                                                the THC or CBD in a prod-
                                                                                                                                uct will be absorbed. Some
                                                                                                                                potency will always be lost
                                                                                                                                in the digestive system be-
            In this Friday, Aug. 16, 2019, photo, chemist David Dawson displays various samples of marijuana while being interviewed at CW   fore it hits the bloodstream,
            Analytical Laboratories in Oakland, Calif.                                                                          she said.
                                                                                                               Associated Press   But  for  now,  exactly  what

            By CARLA K. JOHNSON          this  week,  is  one  example   tors have patented ways of  Markus Roggen, a Vancou-   happens in the human body
            AP Medical Writer            of chemistry’s growing role   putting  cannabis  into  milk,  ver, British Columbia-based  with most of these products
            How much marijuana is re-    in  the  marijuana  industry.   coffee pods, ice pops and  chemist organizing the pro-  is  unclear,  Vialpando  said,
            ally  in  that  pot  brownie?  Besides chocolate’s quirks,   chewing gum.              gram. That’s a big change  because there’s been very
            Chocolate  can  throw  off  chemists  are  working  on    “There’s  a  lot  of  flash  and  from a few years ago when  little  safety  testing  of  can-
            potency  tests  so  labels  extending  shelf  life,  mim-  hipness, snake oil and mar-  presenters didn’t get much  nabis emulsions in animals,
            aren’t  always  accurate,  icking  marijuana’s  earthy    keting. But there’s still a lot  beyond the basics such as:  much less in humans. In Ot-
            and  now  scientists  are  try-  aroma  and  making  prod-  of  real  chemical  advance  “This is THC. This is CBD.”  tawa, Ontario, a Canadian
            ing to figure out why.       ucts  safer.  The  marijuana   happening,”    Capuano  Some  in  the  marijuana  in-   government lab  is  working
            In  states  where  marijuana  business  is  at  a  crossroads   said  of  the  industry.  “It’s  dustry hold “a mythical be-  on a sensor to help police
            is legal, pot comes in cook-  in  its  push  for  legitimacy.   right  in  center  field  for  lief in the goddess of can-  identify  stoned  drivers.  The
            ies, mints, gummies, protein  The federal government still   chemists.”                nabis,”  Roggen  said,  but  goal  is  to  detect  canna-
            bars — even pretzels. These  considers marijuana illegal,   Marijuana  contains  hun-  chemists  view  marijuana  binoid  molecules  in  saliva
            commercial  products  are  yet more than 30 U.S. states   dreds of chemicals, includ-  more  objectively.  For  its  or  breath  droplets,  using
            labeled  with  the  amount  allow it for at least medical   ing  cannabinoids  such  as  part, the industry is learning  light and nanoparticles. Still
            of high-inducing THC. That  use.  Even  in  those  states,   THC  and  CBD,  a  trendy  to accept the “new guard  years  away  from  roadside
            helps  medical  marijuana  there  are  no  recognized     ingredient  with  unproven  of scientists with a different  use,  the  technology  might
            patients  get  the  desired  standard methods for test-   health  claims.  Some  pose  approach to the plant,” he  someday  also  be  used  by
            dose and other consumers  ing products for safety and     challenges  when  they’re  said.                          marijuana  growers  to  de-
            attune their buzz.           quality.                     processed.  Chocolate  is  a  Another  focus  of  research  termine  the  peak  time  to
            But something about choc-    Chemists  working  for  mari-  good example.              is  a  group  of  chemicals  harvest,  said  chemist  Li-Lin
            olate,  chemists  say,  seems  juana companies and test-  “The  chocolate  itself  is  af-  called  terpenes  that  give  Tay, who leads the work for
            to  interfere  with  potency  ing  labs  are  developing   fecting  our  ability  to  mea-  the  marijuana  plant  its  National Research Council
            testing.  A  chocolate  la-  those standards and some     sure   the   cannabinoids  pungent aroma. Many ter-       of Canada.
            beled  as  10  milligrams  of  are legally protecting their   within it,” said David Daw-  penes get lost or changed  To do his work with choco-
            THC  could  have  far  more  ideas.                       son,  chemist  and  lead  re-  in  the  process  of  making  late, Dawson grinds a THC-
            and send someone to the  Scores of cannabis-related       searcher  at  CW  Analytical  a  THC  or  CBD  extract.  But  infused chocolate bar in a
            emergency room with hal-     inventions  have  received   Laboratories  in  Oakland,  users  want  a  certain  smell  commercial  food  proces-
            lucinations.                 U.S. patents, said Boston at-  California, which tests mari-  and taste, said chemist Jef-  sor,  weighs  samples,  adds
            The  latest  research  on  torney  Vincent  Capuano,      juana.                       frey  Raber.  Raber  heads  solvent  to  the  material  (“It
            chocolate,  to  be  present-  who  holds  a  doctorate  in   The more chocolate in the  the  Werc  Shop,  a  Los  An-  starts  looking  like  choco-
            ed at a San Diego meeting  organic  chemistry.  Inven-    vial,  the  less  accurate  the  geles company that mixes  late milk,” he says), before
                                                                      test  results,  he  found.  He  terpenes from lavender, or-  measuring  the  THC  po-
                                                                      thinks  some  of  the  THC  is  anges,  black  pepper  and  tency.  He’s  tested  cocoa
                                                                      clinging to the fat in choc-  other  plants  to  mimic  the  powder, baking chocolate
                                                                      olate,  effectively  hiding  flavor and scent of canna-   and white chocolate to try
                                                                      from the test.               bis  varieties.  The  mashups  to determine what ingredi-
                                                                      Dawson’s research is on the  are sold to companies who  ents are hiding the THC dur-
                                                                      agenda  at  the  American  add  them  to  oils,  tinctures  ing testing.
                                                                      Chemical  Society  meeting  and foods.                    This will lead to better test-
                                                                      in  San  Diego.  The  confer-  Monica  Vialpando,  a  San  ing  standards  and  safer
                                                                      ence  includes  20  presen-  Francisco  chemist,  is  work-  products, he said.
                                                                      tations  about  marijuana’s  ing  to  prevent  drinks  with  “We need good ‘capital S’
                                                                      technical  challenges,  said  CBD and THC oils from sep-  science,” he said.q
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