Page 1207 - Basic _ Clinical Pharmacology ( PDFDrive )
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Index 1193
nedocromil, 355–356, 362t pharmacology of, 124–129 Autonomic synapses, 93
preparations available, 362t structure of, 125, 125f Autonomic transmission, 103, 104t
preventive uses of, 360 Autacoids, renal, 259 Autoplex, 623
sympathomimetics, 349–352, 350f, 362t Autoclaving, 901 Autoreceptors, 100, 102t
beta 2 -selective, 351 Autoimmune disorders, 996. See also specific Autosomal dominant hypophosphatemia,
toxicities of, 351–352 types 787–788
Astrocytes, 368 Autoimmune (type II) drug reactions, Autosomal dominant polycystic kidney
AT 1 , 304 982–983, 999 disease, 268
AT 2 , 304 Autoimmunity, 984 Autosomal recessive hypercholesterolemia
Atazanavir, 74, 87, 871t, 879–880 Autologous stem cell transplantation, (ARH), 631
Atenolol, 164t, 165, 170t. See also G-CSF for, 603–604 Avastin, 1065
b-receptor antagonist drugs Autonomic failure, pure, 137, 155 AV nodal block, 234–236, 235f
angina pectoris treated with, 210t Autonomic motor nerves, 90f Axon, 368
hypertension treated with, 179t, 183, Autonomic nervous system (ANS), 90–93 Azapropazone, 649
191t anatomy of, 90f, 90–93, 91f Azathioprine
structure of, 163f enteric nervous system in, 91f, 91–92 antirheumatic actions of, 650
Atezolizumab, 992 ergotropic, 100 immunosuppressive uses of, 988
Atherogenesis functions of, 89 inflammatory bowel disease treated with,
description of, 627 on immune function, 89 1109–1110
nitric oxide prophylaxis against, parasympathetic division of, 90f, 90–91 TPMT on metabolism of, 81
342–343, 343f somatic division of, 89 Azelaic acid, 1078
Atherosclerosis, 209 sympathetic division of, 90f, 90–91 Azilsartan, 189
Athetosis, 492, 505 trophotropic, 100 Azithromycin, 820, 824t
Atomoxetine, 151 Autonomic pharmacology, 89–106. See also Azoles, 856–859, 861t
Atonic seizures, 430. See also Seizures specific agents adverse effects of, 857–858
Atorvastatin, 632–634, 639t autonomic nervous system in, 90–93. chemistry and pharmacokinetics of,
Atosiban See also Autonomic nervous 856–857, 857f, 858t
description of, 681, 684t system (ANS)) clinical uses of, 857–858
preterm labor managed with, 206 in eye, 105b, 105f dermatologic
Atovaquone, 919f, 926 functional organization of, 100–103 oral, 1073
Atovaquone-proguanil, 920t cardiovascular function integration in, topical, 1072
Atracurium. See also Neuromuscular 100, 102f drug interactions of, 857–858,
blocking drugs central integration in, 91f, 100, 101t, 1159t–1160t
pharmacokinetics of, 477 103 fluconazole, 857f, 858, 858t
properties of, 478t direct effects on organ systems of, itraconazole, 857f, 858, 858t, 861t
structure of, 476f 100, 101t ketoconazole, 857f, 858, 858t, 861t
Atrial fibrillation postsynaptic regulation in, 103, 103f mechanisms of action and resistance to,
antiarrhythmic agents for, 249b presynaptic regulation in, 100, 102t, 857
electrocardiogram of, 236f 103 posaconazole, 858t, 859
with left ventricular dysfunction, 228, functions of, 89–90 preparations available, 862t
253 neurotransmitter chemistry in, 90f, topical, 860–861
Atrial flutter, ECG of, 236f 93–98 voriconazole, 857f, 858t, 858–859
Atrial natriuretic peptide (ANP) adrenergic transmission in, 95–97, Azo reductions, 61t
description of, 34, 308–309, 309f 96f–97f Aztreonam, 806, 812t
on kidney, 259 cholinergic and noradrenergic fibers
mechanism of action of, 28 in, 90f, 93 B
Atrioventricular (AV) node, 228, 229f cholinergic transmission in, 93–95, B 1 receptor antagonists, 307
Atropine, 124–129, 130t. See also 94f B 2 receptor agonists, 308
Muscarinic receptor blockers cotransmitters in, 93 B 2 receptor antagonists, 307–308
actions of, 353 cotransmitters in cholinergic and Babesiosis, 924
chemistry and pharmacokinetics in, 125, adrenergic nerves in, 97–98 Bacillus subtilis, 811
125f nonadrenergic, noncholinergic neurons Bacitracin, 811, 1070
cholinergic poisoning treated with, 132 in, 91f, 97 Baclofen
clinical pharmacology of, 130–133 pharmacologic modification of for dependence and addiction, 588
discovery of, 353 autonomic function in, 103, spasmolytic actions of, 485–487, 486f,
elimination of, 125 104t, 105 489t
intoxication with, 119 receptors in, 98–99, 99t Bacterial cell wall, penicillins on, 797, 797f
pharmacodynamics of, 125–129 Autonomic receptors, 98–99, 99t Bacterial food poisoning, 1034