Page 1211 - Basic _ Clinical Pharmacology ( PDFDrive )

Index 1197

Calcitriol, 775 Canakinumab, 657, 994 Carboxypenicillins, 801. See also
for bone homeostasis, 789t. See also Cancer. See also specific cancer Penicillin(s)
Vitamin D causes of, 948–949 Carcinoid tumor, 292
chronic kidney disease treated with, 785 chemotherapy for, 948–976. See Cardiac arrhythmias, 228–253.
psoriasis treated with, 1078–1079 Chemotherapy See Arrhythmias, cardiac
rickets treated with, 788 epidemiology of, 948 Cardiac cell membrane, active, 230–232,
Calcium from female hormonal contraceptives, 231f
for bone, 789t, 790t 735–736 Cardiac contractility
on bone homeostasis, 773, 773f treatment modalities for, 949–950 modulation therapy for chronic heart
enteric oxaluria treated with, 789 Candesartan failure on, 223
hyperphosphatemia treated with, 784 heart failure treated with, 224t normal, control of, 213, 215
hypocalcemia treated with, 783–784 hypertension treated with, 189 normal control of, 214f
in membrane electrical activity, on vasoactive peptides, 316t Cardiac glycosides, 213. See also Digitalis;
229–230, 230f Cannabinoid receptor inverse agonist, 589t Digoxin
Calcium abnormalities Cannabinoids, 577t, 581–582 drug interactions of, 1165t
hypercalcemia, 782–783 antiemetic properties of, 1106, 1116t heart failure treated with, 213, 217–220,
hypocalcemia, 783–784 G io protein-coupled receptor activation 219f, 225t
Calcium carbonate, 1089 by, 577t, 581–582, 583f Cardiac muscle
Calcium channel blockers Capacity-limited elimination, 45–46 calcium channel blocker effects on,
angina pectoris treated with, 194, Capacity-limited protein binding, 53 204–205
202–206, 210t Capecitabine sarcomere of, 213, 214f
arrhythmia treated with, 245–246, 251t description of, 958t, 959 Cardiac output, 174, 444
diltiazem, 239t, 240t, 246, 251t dihydropyrimidine dehydrogenase on, 78 Cardiac performance, 216f, 216–217
verapamil, 239t, 240t, 245–246, 251t Capreomycin, 843t, 847 Cardiac resynchronization, for chronic
chemistry and pharmacokinetics of, Capromab pendetide, 993 heart failure, 223
202–203, 203t Capsaicin, 99, 372 Cardiac rhythm, 228–233
chronic heart failure treated with, 222 Capsaicin receptors (TRPV1, TRPA1), 560b active cell membrane in, 230–232, 231f
clinical use of, 206 Captopril ionic basis of membrane electrical
discovery and history of, 202 heart failure treated with, 220, 224t activity in, 229–230, 230f
drug interactions of, 1162t hypertension treated with, 179t, nodes and conduction in, 228, 229f
hypertension treated with, 179t, 187–188, 192t potassium effects in, 231b
186–187, 193t on renin-angiotensin system, 305 resting potentials on action potentials in,
mechanism of action, 205 on vasoactive peptides, 316t 232–233, 233f
migraine headache prophylaxis using, Carbachol, 109, 109f, 122t Cardiovascular system
291 Carbamate pesticides, 1012, 1012t alcohol effects on, 398, 401
nitrates with, 208, 209t Carbamazepine, 529t autonomic integration of, 100, 102f
pharmacodynamics of, 203t, 203–205 bipolar disorder treated with, 528, 529t cholinesterase inhibitors effect on, 118
poisoning management for, 1041t, 1043 drug interactions of, 1162t–1163t contraceptives on, female hormonal, 734
preparations available, 211t, 251t seizures treated with, 413–417, 415f, histamine effects on, 279
smooth muscle contraction affected by, 433t, 438t kinins on, 306–307
196f, 197 Carbamic acids, 115, 116f lead exposure effects on, 1022–1023
toxicity of, 205 Carbapenems, 796f, 807, 812t methylxanthines effect on, 353
Calcium channels, voltage-activated, 203t Carbaryl, 115, 116f Cardioverter-defibrillator, implantable,
2+
Calcium ion (Ca ) Carbidopa, 495f, 508t. See also Parkinsonism 246b
description of, 30 Carbidopa-levodopa, parkinsonism, 495, Carfentanil, 568
as second messenger, 32–34, 34f 495f, 508t Carfilzomib, 966t, 971
Calcium oxalate stones, 789 Carbimazole, 693–695, 694f Cariprazine, 515, 529t
Calcium receptor agonists, 790t Carbinoxamine, 283t Carisoprodol, 488, 489t
hyperparathyroidism treated with, 784, Carbonic anhydrase inhibitors, 259–261, Carmustine, 953f, 955t
790t 260t, 272t, 274t, 432 Carperitide, 310. See also Natriuretic
preparations available, 790t Carbon monoxide peptides
Calcium-sensing receptor (CaSR), 781 description of, 1006–1007, 1007t heart failure treated with, 220
cAMP (cyclic adenosine-3′,5′- poisoning, 1041t, 1043, 1044t kidney effects of, 259
monophosphate), 30, 302, 302f Carbonyl reductions, 61t on vasoactive peptides, 317t
Camptothecins, 962t, 964 Carboplatin, 955t, 956–957 Carprofen, 649
Canagliflozin Carboprost tromethamine Carrier molecules, special, 8, 8f
description of, 261–262, 272t, 274t abortion uses of, 334 Carteolol, 164t, 166, 170t, 183. See also
diabetes mellitus treated with, 763, 769t structure of, 333f b-receptor antagonist drugs