Page 1232 - Basic _ Clinical Pharmacology ( PDFDrive )

1218 Index

Hypertension (Cont.): pharmacodynamics of, 386–389 Ibutilide, 239t, 240t, 245, 251t
essential, 174 pharmacokinetics of Icatibant. See also Kinin inhibitors
etiology of, 174 absorption and distribution, 386 description of, 187, 307, 317t
malignant, 190 biodisposition, 386 on vasoactive peptides, 316t
nutritional supplements for, 1141 biotransformation, 385t, 386 Idarubicin, 962t, 965
portal, 1114 excretion, 386 Idarucizumab, 618
pulmonary Hypocalcemia, 783–784 Idelvion, 621
eicosanoids for, 335 Hypofibrinogenemia, 622t Idiopathic edema, 271
nitric oxide for, 344 Hypoglycemia, 767 Idiopathic hypercalciuria, 788
preparations available, 318t Hypoglycemic unawareness, 767 Idiopathic short stature, 671
treatment of, 313b Hypogonadism, primary, 725 Idiopathic thrombocytic purpura (ITP),
renin-angiotensin system suppression for, Hypokalemia, 231b, 270 1180t
300, 320 Hypokalemic metabolic acidosis Idiosyncratic drug response, 38
resistant, polypharmacy and, 177b from loop diuretics, 263 Idrocilamide, 487
risk factors for, 174 from thiazide diuretics, 265 IFNL3 (IL-28B), 77t, 80t, 85
secondary, 174 Hypomagnesemia, from loop diuretics, 263 Ifosfamide, 953. See also Alkylating agents
Hypertensive emergencies Hyponatremia IGF-I agonist, 672, 682t
alpha-receptor antagonists for, 161 from mannitol, 268 IL-28B, 77t, 80t, 85
description of, 190–191 from thiazide diuretics, 265 Iloprost (PGI 2 analog), 324f
Hypertensive encephalopathy, 190 Hypoparathyroidism, 784–785 pulmonary hypertension treated with, 335
Hyperthermia, malignant, 288t Hypophosphatemia, 784 structure of, 333f
anesthetics as cause of, 449, 483 autosomal dominant, 787–788 Imatinib, 35, 966t, 967
dantrolene for, 449, 488 X-linked, 787–788 131 I-meta-iodobenzylguanidine (MIBG),
succinylcholine as cause of, 449, 483 Hyporeactive, 38 160
Hyperthermic syndromes, 288b, 288t Hypotension, renal response to, 175 Imidazoline receptor, clonidine binding to,
Hyperthyroidism, 698–699 Hypothalamic-pituitary-adrenal axis, 533 180
amiodarone-induced thyrotoxicosis, 700 Hypothalamic-pituitary endocrine system, Imipenem, 803t, 807, 812t
dermopathy, 699 667, 668f Imipramine, 537, 540t, 542t, 550t. See also
Graves’ disease, 698 Hypothalamic-pituitary-thyroid axis, Muscarinic receptor blockers;
neonatal, 700 689, 691f Tricyclic antidepressants (TCAs)
manifestations of, 694t Hypothalamus dosing of, 546t
ophthalmopathy, 699 description of, 667, 668f urinary disorders treated with, 132
subacute thyroiditis, 699 hormones and receptors of, 668f, Imiquimod, 893, 1074
subclinical, 700 668–670, 669t Immediate effects, 48–49, 49f
thyroid storm, 699 Hypothyroidism, 696–698 Immediate (type I) drug allergy, 982, 983f,
thyrotoxicosis in pregnancy, 700 congenital (cretinism), 691, 696t 998–999
toxic multinodular goiter, 699 drug-induced, 692t, 696t, 697–698 Immobility, in anesthesia, 447b
toxic uninodular goiter, 699 on drug metabolism, 72 Immune function, autonomic nervous
Hypertriglyceridemia etiology and pathogenesis of, 696, 696t system on, 89
familial, 629t, 630 management of, 696–698 Immune globulin (IM)
primary, 629t, 629–630 manifestations of, 691, 694t, 696 measles treated with, 1180t
chylomicronemia, primary, 629t, myxedema and coronary artery disease, rubella treated with, 1181t
629–630 697 Immune globulin intravenous (IGIV),
familial combined myxedema coma, 697 990–991
hyperlipoproteinemia, 630 pregnancy and, 697 bone marrow transplantation uses of,
familial combined subclinical, 697 1180t
hypertriglyceridemia, 629t chronic lymphocytic leukemia treated
familial dysbetalipoproteinemia, 629t, I with, 1180t
630 Ibandronate complications of, 1175
familial hypertriglyceridemia, 629t, 630 on bone homeostasis, 779–781, 789t hepatitis A treated with, 1180t
fundamentals of, 629 bone metastases and hypercalcemia hepatitis B treated with, 1180t
secondary, 629t treated with, 789t in HIV-infected children, 1180t
Hyperuricemia, 659–660 osteoporosis treated with, 786, 789t idiopathic thrombocytic purpura treated
from loop diuretics, 263 Ibritumomab tiuxetan, 993 with, 1180t
treatment of. See Gout Ibuprofen. See also Nonsteroidal anti- immunodeficiency disorders treated
Hypnotics, 381, 394t. See also Sedative- inflammatory drugs (NSAIDs) with, 1180t
hypnotic drugs; specific types description of, 644f, 645t, 647–648 Kawasaki disease treated with, 1180t
clinical pharmacology of, 390t on eicosanoid synthesis, 332 rabies treated with, 1180t