Page 1230 - Basic _ Clinical Pharmacology ( PDFDrive )

1216 Index

Hemodialysis, for poisoning, 1039t, 1040 Heroin. See also Opioid agonists HMG-CoA reductase, 628f
Hemoglobin A1c, 752–753 description of, 567 HMG-CoA reductase inhibitors
Hemophilia A, 621–623, 622t G io protein-coupled receptor activation with bile-acid binding resins, 639
Hemophilia B, 621–623, 622t by, 581, 583f competitive, 632–634, 633f, 639t
Hemophilia C, 622t Herpes simplex virus (HSV), 864–867 drug interactions of, 1166t–1167t
Hemorrhage, postpartum, 295 acyclovir for, 865t, 866, 866f with ezetimibe, 639
Henbane, 125. See also Muscarinic receptor docosanol for, 865t, 867 with fenofibrate, 639
blockers famciclovir for, 865t, 867 with niacin, 639
Henderson-Hasselbalch equation penciclovir for, 865t, 866f, 867 sites of action of, 631f, 632–633
description of, 9 trifluridine for, 865t, 866f, 867 HMG-coenzyme A (CoA) reductase
for local anesthetics, 459 valacyclovir for, 865t, 866–867 inhibitors, OATP1B1 on, 83
Heparin, 612f, 612–616 valomaciclovir, 867 Homatropine, 130t, 135t. See also
administration and dosage of, 613–614 12(S)-HETE, 325, 331 Muscarinic receptor blockers
chemistry of, 612, 612f 12(R)-HETE, 331 Homeostatic responses, for cardiovascular
contraindications to, 613 20-HETE, 325, 332 function, 100, 102f
mechanism of action of, 612, 612f Heterodimers, 31 Homodimers, 31
monitoring of, 612 Heterologous desensitization, 141 Homologous desensitization, 141
pulmonary embolism treated with, case Heteroreceptors, 100, 102t Hookworms. See also Anthelmintic drugs
study of, 608, 625 Heterozygous familial hypercholesterolemia, albendazole for, 938–940, 939t
reversal of action of, 614 626, 641 mebendazole for, 942
toxicity of, 613 Hexachlorocyclohexane, 1075 Hormone replacement therapy (HRT).
Heparin-induced thrombocytopenia (HIT), Hexachlorophene, 899 See also Gonadal hormones and
613 Hexamethonium, 133–134, 134f. See also inhibitors, 720–746
Hepatic disease, 72. See also specific disease Ganglion blockers postmenopausal, estrogens for, 725–726
Hepatic encephalopathy, 261 High-density lipoprotein (HDL), 626, premature ovarian failure treated with,
Hepatitis 627–628, 628f 720
drugs for, 884t, 884–891. See also High-molecular-weight (HMW) heparin, Hormones
Antihepatitis agents 612f, 612–614. See also Heparin description of, 3. See also specific
halothane, 449 Hirsutism, 726, 734 hormones
Hepatitis A vaccine, 1176t Hirudin, 617 secretion of, catecholamines effect on,
Hepatitis B His-Purkinje system, 228, 229f 148
treatment of, 863, 894 Histamine and histamine agonists, 277–281 Horner’s syndrome, 153b
vaccine for, 1176t chemistry and pharmacokinetics of, 278 Host factors, in antimicrobial choice, 905
Hepatitis B immune globulin (HBIG), 1180t clinical uses of, 281 Household bleach, 899
Hepatitis C virus (HCV) life cycle, 887 in CNS, 376t, 379 5-HT 3 -antagonists, antiemetics,
Hepatocellular cancer, 973 history of, 278 1103–1105, 1116t, 1117t
Hepcidin, 592 pharmacodynamics of, 279–280 5-HT 1D / 1B agonists, 289–291, 290f, 291t
Hepoxilins, 325 storage and release of, 278 5-HT receptor modulators, 550t. See also
Herbal medications, 1131–1141, 1133t Histamine receptor antagonists, 281–285, Antidepressant agents
clinical aspects of, 1132 296t chemistry of, 538
echinacea, 1134–1136 H 1 -receptor, 281–284 clinical pharmacology of
garlic, 1135–1136 chemistry and pharmacokinetics of, adverse effects in, 547
ginkgo, 1136–1137 281, 282f, 283t drug interactions in, 548–549
ginseng, 1137–1138 clinical pharmacology of, 283–284 pharmacodynamics of, 542t, 543
historical and regulatory facts on, 1132 pharmacodynamics of, 281–283, 283t pharmacokinetics of, 540t, 541
history of, 1132 H 2 -receptor, 284–285 preparations available, 551t
literature on, 1131 H 3 - and H 4 -receptor, 285 Huffing, 585
milk thistle, 1138–1139 preparations available, 297t–298t Human chorionic gonadotropin (hCG)
saw palmetto, 1141 Histamine receptors chemistry and pharmacokinetics of, 674
St. John’s wort, 1139–1140 description of, 279t, 279–280 male infertility treated with, 675
toxicity of, 3 H 2 parietal cell, 1087–1088, 1088f pharmacodynamics of, 674
Herbicides, 1013–1014 Histrelin, 676 properties of, 683t
bipyridyl (paraquat), 1013f, 1014 HIV, 870. See Human immunodeficiency Human immunodeficiency virus (HIV)
chlorophenoxy (2,4-D), 1013f, virus (HIV) AIDS from, 984–985
1013–1014 HLA polymorphisms in children, immune globulin
glyphosate, 1013f, 1014 in hypersensitivity reactions, 83t, 83–85, intravenous, 1180t
Hereditary angioedema, kinins in, 307 84f with HBV in alcoholic smoker on
Hereditary vitamin D–resistant rickets, 788 types of, 77t, 80t methadone, 863, 894