Page 1235 - Basic _ Clinical Pharmacology ( PDFDrive )

Index 1221

Irbesartan Isoprostanes, 326 aminolevulinic acid, 1084
hypertension treated with, 189 Isoproterenol, 146f, 146t, 149. See also fluorouracil, 1083
on vasoactive peptides, 317t Sympathomimetics, direct-acting ingenol mebutate, 1083–1084
Irinotecan asthma treated with, 351, 362t NSAIDs, 1084
description of, 962t cardiovascular responses to, 146t podophyllum resin and podofilox, 1083
UGT1A1 on metabolism of, 79t, 81 structure of, 144f, 350f propylene glycol, 1082
Iron, 592–596, 593f, 594t Isosorbide dinitrate salicylic acid, 1082
clinical pharmacology of, 593f, 594–596 angina pectoris treated with, 198, 202t, sinecatechins, 1083
indications in, 594t, 594–595 209t urea, 1082–1083
oral iron therapy, 595, 595t heart failure treated with, 225t Ketamine
parental iron therapy, 595–596 Isosorbide dinitrate/hydralazine (BiDil), abuse of, 577t, 580
toxicity of, 596 222 analgesic uses of, 560b
drug interactions of, 1167t Isosorbide mononitrate, 198, 202t, 209t. anesthesia uses of, 450f, 450t, 456–457,
female hormonal contraceptives effect See also Nitrates and nitrites 535
on, 733 Isotretinoin, 1077–1078 depression treated with, 535–536
in hematopoiesis, 592 Isoxazolyl penicillins, 801 enantiomers of, 4
pharmacokinetics of, 592–594, 593f, Isradipine ionotropic receptors in, 585
594t angina pectoris treated with, 203t Ketanserin, 292, 297t. See also Serotonin
pharmacology of, 592 hypertension treated with, 187 (5-HT) receptor antagonists
poisoning management for, 1045 Istaroxime, for heart failure, 219 Ketoacidosis, diabetic, 767
preparations available, 607t Itraconazole, 857f, 858, 858t, 861t Ketoconazole, 1072
toxicity of, clinical, 596, 606t dermatologic, 1073 adrenocortical antagonist action of, 715,
Iron-deficiency anemia, 592–596, 593f, Ivabradine 716f
594t angina pectoris treated with, 207, 210t as antiandrogen, 743–745
Iron dextran, 595, 605t arrhythmia treated with, 247 as antifungal, 857f, 858, 858t, 861t
Iron overload, 596, 605t chronic heart failure treated with, 222 dermatologic, topical, 1072
Iron sucrose complex, 595, 605t Ivacaftor, 24, 248b, 252t topical, 861t
Irreversible antagonists, 23f, 24 Ivermectin Ketolides, 820–821, 824t
Irreversible cholinesterase inhibitors, 117 ectoparasiticidal action of, 1075 Ketone bodies, 753
Irrigation, whole bowel, 596 helminths treated with, 939t, 941–942 Ketones (inhalants), ionotropic receptors
Irritable bowel syndrome Ixabepilone, 963 in, 585
description of, 1101–1102 Ixekizumab, 994 Ketoprofen, 645t, 648
drugs for, 1101–1103, 1115t Ketorolac, 659
antispasmodics, 1101–1102 J Kidney
chloride channel activators, 1103 JAK/STAT receptors, 667 angiotensin II on, 303
serotonin 5-HT3-receptor antagonists, Janus-kinase (JAK) family, 28–29, 29f excretion from, manipulation of, 9, 11f
1102, 1102f, 1116t, 1117t Jaw, osteonecrosis of, 780 lead exposure effects on, 1022
Isavuconazole, 859, 861t Jet lag, 1143–1144 methylxanthines effect on, 353
Isavuconazonium sulfate, 859 Jimson-weed, 125. See also Atropine; nephron segments and functions in,
Ischemic heart disease, 167f, 167–168, 168f Muscarinic receptor blockers 256t
Islet amyloid, 769t Jin Bu Huan, 1133t tubule transport mechanisms in,
Islet amyloid polypeptide (IAPP) analogs, Jod-Basedow phenomenon, 695 254–259. See also Renal tubule
747, 764, 769t Jublia, 1072 transport mechanisms
Isocarboxazid, 546t Juxtaglomerular cells, 301 Kidney disease. See also specific types
Isoeicosanoids, 326 chronic, 785–786
Isoflurane, 441–449. See also Anesthetics, K from diuretics, 254, 275
inhaled Kainate receptors, CNS, 375 diuretics for, 270–271
properties of, 443t Kainic acid (KA), CNS, 375 Kidney stones
structure of, 443f Kallikrein-kinin system, 306f carbonic anhydrase inhibitors as cause
Isolated systolic hypertension, 174 description of, 306 of, 261
Isoniazid drugs affecting, 307–308, 317t potassium-sparing diuretics as cause of,
phase II activation of, 57, 57f Kallikreins, 306 267
tuberculosis treated with, 842–845, Kanamycin, 831–832, 848 Kininase II, in angiotensin biosynthesis,
843t, 851t Kappa opioid receptors, 553, 554t 303
Isopropyl alcohol (isopropanol) Kava-kava, 1133t Kinin inhibitors, 307–308, 317t
antisepsis and disinfection uses of, 898, Kawasaki disease, 1180t preparations available, 318t
898t Kefauver-Harris Amendment, 15, 16t on vasoactive peptides, 316t
ingestion of, 405 Keratolytic and destructive agents Kininogens, 306