Page 1239 - Basic _ Clinical Pharmacology ( PDFDrive )

Index 1225

Mesolimbic dopamine system, 576, 576f, lead, 1020–1025, 1021t description of, 149, 191t
579b mercury, 1021t, 1027–1029 hypertension treated with, 179t,
Mesolimbic-mesocortical pathway, 516 poisoning management for, 1045 179–180
Mesothelioma, 1017 Metals, toxic Methylenedioxymethamphetamine
Mestranol, 723f. See also Estrogen(s) beryllium, 1017 (MDMA), 587, 589t
Meta-analyses, 15b cadmium, 1017 Methylmercury, 1028
Metabolic acidosis nanomaterials, 1017–1018 Methylnaltrexone (bromide), 571, 572t,
hyperchloremic poisoning management for, 1045 1099
from carbonic anhydrase inhibitors, Metaproterenol Methylphenidate, 150
261 asthma treated with, 351, 362t Methylprednisolone, 709t. See also
from potassium-sparing diuretics, 267 structure of, 350f Corticosteroids, synthetic
hypokalemic Metastasis, 948 antiemetic properties of, 1105
from loop diuretics, 263 Metaxalone, 488 asthma treated with, 355, 362t
from thiazide diuretics, 265 Metformin, 759–760, 768t, 1058 Methyltestosterone, 740–743, 741t. See also
Metabolic alkalosis Methacholine, 109, 109f Androgens and anabolic steroids
carbonic anhydrase inhibitors for, Methadone, 555t, 556, 567, 572t, 581, Methylxanthine drugs. See also specific drugs
260–261 588t. See also Opioid agonists asthma treated with, 352f, 352–353,
diuretic-induced, 270 Methallenestril, 723, 723f. See also 362t
Metabolic syndrome, 289b Estrogen(s) preparations available, 363t
Metabolism, drug Methamphetamine, 11f, 150. See also Methysergide, 295
clinical relevance of, 64–72 Methylenedioxymethamphet- Metoclopramide, 1097–1098, 1106
age and sex in, 70 amine (MDMA) Metolazone, 264f, 264t, 269, 273t
commensal gut microbiota in, 69–70 Methanol Metoprolol, 164t, 165, 170t, 191t. See also
diet and environmental factors in, 70 description of, 405, 405f, 406t b-receptor antagonist drugs
diseases on, 72, 72t poisoning management for, 1041t, 1045 angina pectoris treated with, 210t. See also
drug-drug interactions in, 70–72, 71t Methazolamide, 260t b-receptor antagonist drugs
drug-endogenous compound interac- Methemoglobin, 199 heart failure treated with, 221,
tions in, 72 Methenamine hippurate, 897, 902t 222, 225t
drug interactions on, 1173 Methenamine mandelate, 897, 902t hypertension treated with, 179t, 183
drugs enhancing, 70, 71t Methicillin, 801 structure of, 163f
drugs inhibiting, 71t, 72 Methicillin-resistant staphylococci, cephalo- Metrifonate, 939t, 943
genetic factors in, 65–69 sporins for, 802f, 803t, 804–806 Metronidazole, 895–896, 902t
phase I enzyme polymorphisms in, Methimazole, 693–695, 694f, 701t, 702 acne treated with, 1071
65–69, 66t–67t, 68f Graves’ disease treated with, 698 amebiasis treated with, 929t, 929–930,
phase II enzyme polymorphisms in, thyroid storm treated with, 699 930f
64f, 69 thyrotoxicosis in pregnancy treated with, Metyrapone, 716, 716f
genetic variations in, 75–82 700 Metyrosine, 95, 161, 171t
phase I enzymes, 74–81 toxic multinodular goiter treated with, Mexiletine
phase II enzymes, 81 699 arrhythmia treated with, 239t, 240t,
individual differences in, 65 Methocarbamol, 488, 489t 242, 250t
to toxic products, 64–65, 65f Methohexital, 450t on ion channels, 560b
ultrarapid, 67 Methotrexate (MTX) Mibefradil, 204. See also Calcium channel
Metabolism, intermediate asthma treated with, 360 blockers
adrenoceptors in, 148 cancer treated with, 957, 958t Micafungin, 859, 861t
sympathomimetics on, 148 immunosuppressive uses of, 989 Miconazole, 1072
Metabolizer inflammatory bowel disease treated with, Microbiota, commensal gut, 69–70
extensive, 68, 75t 1110, 1116t Microglia, 368
poor, 67, 75t rheumatoid arthritis treated with, Micro-RNAs (miRNAs), 2, 39
ultrarapid, 67, 75t 651–652 Microsomal drug oxidation, 58–59,
Metabotropic glutamate receptor agonists, Methoxamine, 144f 60t–61t
516 Methoxsalen, 1076 Microsomal ethanol-oxidizing system
Metabotropic (metabolic) receptors, CNS, Methoxy polyethylene glycol–epoetin beta, (MEOS), 397f, 397–398
369f, 370 601, 606t Microsomal mixed function oxidase system,
Metalloproteins, 340, 340f Methsuximide, 429f 58f, 58–59
Metals, heavy, 901, 1020–1029 Methylbenzene (toluene), 1010 Microsomal triglyceride transfer protein
arsenic, 1021t, 1025–1027, 1027f Methylcellulose, 1098 (MTP) inhibitor, 638
chelators for, 1029–1033, 1033t. See also Methyldopa. See also Sympathomimetics, Microsomes, 58
Chelators direct-acting Midamor, 266t