Page 352 - Basic _ Clinical Pharmacology ( PDFDrive )

338 SECTION IV Drugs with Important Actions on Smooth Muscle

C ASE STUD Y ANSWER

Prostacyclin analogs have been shown to be effective in G protein-coupled IP receptor, leading to elevated cAMP.
the treatment of pulmonary hypertension. Multiple for- The result is reduced proliferation of vascular smooth mus-
mulations are now available including intravenous, inha- cle cells and vasodilation, key strategies in the treatment of
lational, and more recently, oral. These agents activate the pulmonary hypertension.