Page 118 - Atlas of Histology with Functional Correlations

Mitosis consists of four phases—prophase, metaphase, anaphase, and

telophase

Prophase

Condensation of chromosomes to form two identical chromatids

Chromatids are joined together at the centromere
Nuclear envelope and nucleolus disappear
Centrosome divides, and centrioles move to the opposite poles of the cell
Centrioles form microtubules of the mitotic spindle
Microtubules attach to kinetochores of chromatids and align chromosomes in

the middle of the cell

Metaphase

Chromosomes highly condensed

Kinetochore aligns chromosomes along the equator of the cell
Formation of equatorial plate

Anaphase

Chromatid pairs separate at the centromere because of enzymatic action and
become chromosomes
Chromosomes migrate to opposite poles of the cell because of shortening of

kinetochore microtubules
Migrating chromosomes form a V shape in the cell
Cleavage furrow appears at the cell equator

Telophase

Terminal phase of mitosis
Chromosomes complete their migration to the opposite side of the mitotic
spindle

Chromosomes condense to form chromatin of the interphase cell
Nucleolus reappears, and a nuclear envelope is formed
Contractile ring becomes the site of cleavage for separation of daughter cells
Cytokinesis is the division of genetically identical cells during mitosis

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