Page 52 - Book of Abstracts

th
8 Biannual Conference on Chemistry - CHEM 08

New Hydrazone Substituted Molybdenum Carbonyl
Complexes With Good Co-Release Profile and Antibacterial
Activity

Abubakar A. T. and Eke U. B.
2
1
1 Department of Chemistry, Sule Lamido University, Kafin Hausa, P. M.
B. 048, K/Hausa, Nigeria, Department of Chemistry, University of Ilorin,
2
P. M. B. 1515, Ilorin, Nigeria. Email: tendoga07@gmail.com

ABSTRACT
Long term administration of an organic drug molecule will likely
eventually result in drug resistance. Antibiotic drug resistance is
identified as a major setback in battling the scourge of microorganism
infections. Carbon monoxide (CO) releasing transition metal carbonyls are
a new class of metal containing compounds with potential as
antimicrobial agents effective against drug resistant pathogens.
Substitution reaction of molybdenum hexacarbonyls with biologically
relevant hydrazone moieties mediated by trimethylamine N-oxide were
carried out under nitrogen atmosphere. The hydrazones stabilized
tricarbonyl complexes I – IV, Fig 1, were characterized by spectroscopic
techniques and elemental analysis revealing three CO ligands, two of
which are in trans position in a C2v symmetry giving rise to a meridional
geometry. Investigation of CO release properties of the tricarbonyls
showed they liberated CO in solution at rates comparable to previously
reported CO-releasing molecules. Antibacterial examination unveiled that
with the exception of Mo(SIH)3(CO)3 (II), all the complexes displayed
good bactericidal action against E. coli, S. aureus and P. aeruginosa with
activity dependent on CO release and the chemical nature of the ancillary
ligand. Activity of I and IV surpass that of a standard antibiotic used as
control.
The species; I, III and IV are therefore strongly recommended as

antibacterial drug candidates.

BOOK OF ABSTRACTS CHEM 08 (2020) Page 51