Page 61 - Book of Abstracts

th
8 Biannual Conference on Chemistry - CHEM 08

Synthesis, Characterization, Anticancer and Biological
Evaluation of a New Schiff Base Derived From the
Condensation of 2-Hydroxybenzaldehyde and Ambroxol

Drug With Some of Transition Metal Ions

Hoda A. Elsawy , Mostafa M.H Khalil, Walaa H. Mahmoud , Gehad G.
Mohamed and Mostafa A. Radwan
Email: hoda.ahmed@bue.edu.eg

ABSTRACT

A new Schiff base was synthesized as the condensation product of
reaction of 2-hydroxybenzaldehyde and ambroxol drug. The synthesized
Schiff base H2L (trans-4-[(2-(2-hydroxybenzimino)-3,5-
dibromobenzyl)amino]-cyclohexanol) is further employed as a tridentate
ligand for the synthesis of new complexes through reaction with the metal

ions of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II). The
synthesized Schiff base H2L along with its metal complexes were
characterized using some physicochemical techniques including
elemental analysis, UV–Vis, FT-IR, thermal analyses (TGA/DTG), mass
spectrometry, conductimetric measurements as well as magnetic
susceptibility. On the basis of these studies, an octahedral geometry for all
these complexes has been proposed. The Schiff base and its complexes
have been screened for their antimicrobial activity against some species of
bacteria and fungi organisms by disk diffusion method. The results
showed that the highest antimicrobial activity is amounted for the Cr(II)
complex. Anticancer activity of the ligand and its metal complexes were
observed in breast cancer cell line (MCF-7 cells viability) and (HFB-4 cell
viability). It can be concluded that the Cu(II) complex had the highest
anticancer activity. Molecular docking was employed to predict the
coordination between H2L ligand and its Zn(II) complex and the receptors
of RNA of amikacin antibiotic (4P20) and Human Serum Albumin (5fuo).
Valuable structural information was provided from the docking study.

BOOK OF ABSTRACTS CHEM 08 (2020) Page 60