Page 96 - Book of Abstracts

th
8 Biannual Conference on Chemistry - CHEM 08

Reactivity of Chloroformazans. Synthesis of 3-
Phenyldiazenyl Spiro Heterocycles and 3-Phenyldiazenyl-
1H-pyrazole Derivatives

Fatma M. Saleh, Mirna T. Helmy and Hamdi M. Hassaneen*
Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt.
Email: hamdi_251@yahoo.com

ABSTRACT

The reactions of N,2-diaryldiazene-1-carbohydrazonoyl chlorides 1-3 with 5-
arylmethelene-3-phenyl-4-oxothiazol-2-thiones 5a-f in acetonitrile at room
temperature in the presense of triethylamine afforded 3-phenyldiazenyl-4,6-
dithia-1,2,9-triazaspiro[4.4]non-2-en-8-one derivatives 7-9. Refluxing of 1-3 with
enaminones 6A-D in chloroform in the presence of triethylamine gave 3-
phenyldiazenyl and 1H-Pyrazole 10-12 derivatives. The structures of new
products 7-9 and 10-12 identified by elemental analysis and spectral data. All
new synthesized compounds were studied against Staphylococcus aureus, Bacillus
subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans and the most
potent compounds 8b, 9b, 16B, 16A and 17A.

Keywords: Chloro formazans, Cycloaddition reaction, Thiadiazoles,
Enaminones and Antimicrobial activity.

BOOK OF ABSTRACTS CHEM 08 (2020) Page 95