Page 98 - Book of Abstracts

th
8 Biannual Conference on Chemistry - CHEM 08

Synthesis, Antimicrobial, Anti-Cancer and

Molecular Docking of Two Novel Hitherto
Unreported Thiophenes

Y.N. Mabkhot, Nabila Abdelshafy Kheder, A. Barakat, M.I. Choudhary, S.
1
4
2
3
Yousuf and W. Frey
5
4
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid
University, Abha, KSA, Department of Chemistry, Faculty of Science, Cairo
2
University, Giza, Egypt, Department of Chemistry, Faculty of Science,
3
Alexandria University, Ibrahimia, Egyp, H.E.J. Research Institute of Chemistry,
4
International Center for Chemical and Biological Sciences, University of
Karachi, Pakistan, Institut für Organische Chemie, Universität Stuttgart,
5
Stuttgart, Germany. Email: nabdelshafy@sci.cu.edu.eg

ABSTRACT
One pot synthesis of two novel hitherto unreported thiophenes was
achieved by a facile and selective synthetic method. The crystal structures
of the synthesized compounds were determined using an X-ray single
crystal technique. The synthesized thiophenes were evaluated for their
anti-cancer and antimicrobial activities. Molecular docking studies of the
synthesized compounds were performed by (MOE). The predicted results
from the molecular docking studies were in complete agreement with the

experimental data for antimicrobial evaluation.

RO
H C O
3
O S O
RO OR i. PhNCS / K CO 3 O
2
O N S NH
O H C
3
1a,b ii. Cl Ph Ph
3a,b
3a: R=Et
3b: R= Me

BOOK OF ABSTRACTS CHEM 08 (2020) Page 97