Page 55 - Pharmaceutical Organic Chemmistry-3 (Theoritical book) 24-25
P. 55
Clinical Pharmacy PharmD - 2024/2025 Level 2 Pharmaceutical Organic Chemistry-3 (PC 305)
Thiamin Penicillin
Benzo- Fused Diazoles
Benzimidazoles:
4 3
N
5
2
6
N 1
7 H
Benzimidazoles are readily obtained by heating o-phenylenediamines with carboxylic acids, e.g.
benzimidazole itself is prepared by heating o-phenylenediamine with formic acid:
N
O
NH 2 + C H N
HO - 2H O
2
H
NH 2 O N
+ C R R
o-phenylenediamine - 2H O
HO 2 N
H
The 5, 6-dimethylbenzimidazole is a part of the structure of vitamin B12
(cobalamin)
