Page 62 - Pharmaceutical Organic Chemmistry-3 (Theoritical book) 24-25

Clinical Pharmacy PharmD - 2024/2025 Level 2 Pharmaceutical Organic Chemistry-3 (PC 305)

CH 3
CH 3

CH
N 3 N N

-picoline -picoline -picoline

(2-picoline) (3-picoline) (4-picoline)

CH
CH 3 3

N CH 3 N CH 3 CH 3 N CH 3

2,3-lutidine 2,4-lutidine 2,6-lutidine

CH 3

CH 3 N CH 3

2,4,6-collidine

3) Halogen derivatives:

-and -Halopyridines resemble o- and p-chloronitrobenzene in being readily

replaced by ammonia, amines and other nucleophilic reagents.

RNH 2
NHR
N

NaOEt
Cl
N OEt
N

aq. NaOH
O--H
N N O
H

6) Pyridine carboxylic acids:

COOH
COOH
COOH
N N N

Picolinic acid nicotinic acid isonicotinic acid

(-carboxylic acid) (-carboxylic acid.) (-carboxylic acid)