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                  Single pill combination of  Amlodipine/ Valsartan has

                    better MACE-free survival than its free combination








                                                        Kaplan - Meier Plot


                  1.00





                 MACE Free Probability  0.95







                  0.90






                  0.85     Drug                                                             P = 0.003
                           ARB + CCB
                           SPC




                  0.80

                         0.0               0.5               1.0               1.5              2.0
                                                       Time (Years)

              Numbers at risk
              ARB + CCB  13204             12563             12123             5782              1203
              SPC         3301             3198              3086              1336              171


                                 Kaplan-Meier survival curves of major adverse cardiovascular events.




              MACEs included any of the following: (1) myocardial infarction (2) heart failure; (3) percutaneous coronary; (4) coronary artery
              bypass surgery; (5) stroke (6) thrombolysis therapy; (7) malignant dysrhythmia and (8) cardiogenic shock.

            MACE: Major adverse cardiovascular events
            J Clin Hypertens (Greenwich). 2015;17:51–58
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