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Uncontrolled hypertension with any other antihypertensive monotherapy

Amlodipine/Valsartan combination pill has superior

BP-lowering effect compared with monotherapy with

its components

Amlodipine Valsartan Amlodipine / Valsartan
10 mg 160 mg 10 / 160 mg
0

-5

-10

-15
-14.5
-16.9

-20

-25
-22.9*

Change from baseline in systolic BP (mmHg) *p<0.01 vs monotherapies Mild-to-moderate
hypertension = diastolic BP >90 and < 110 mmHg N=80

A 4-week placebo period, on 80 with mild-to-moderate hypertension randomized to amlodipine 10mg or valsartan 160mg or
amlodipine 10mg plus valsartan 160mg for 6 weeks according to an open-label, blinded end point, crossover design.

Hum Hypertens.2007;21:220–224