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Amlodipine/ Valsartan single pill combination provides
71% less edema than Amlodipine alone
N=80
Amlodipine increases ankle
25 foot volume by 23%
23.0
Ankle-foot volume increase (%)
20
71%
71%
15 Diff er ence
Difference
produced a significantly less
10 prondouced Increase in AFV
(6.8% increase in AFV)
*p<0.01
5 6.8*
0
Amlodipine 10mg Amlodipine / Valsartan
10 / 160mg
4-week placebo period, 80 grade 1–2 hypertensive patients, SBP>140mmHg and DBP>90mmHg and <110 were randomized to
Amlodipine 10mg or Valsartan 160mg or Amlodipine 10mg plus Valsartan 160mg for 6 weeks.
AFV: ankle foot volume
J Hum Hypertens 2007;21:220– 224
