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Three blood pressure lowering drugs in low dose
combination would reduce stroke by 60% and heart
disease by 50%
Three drugs at half standard dose are estimated to lower blood pressure
by 20 mmHg systolic and 11 mmHg diastolic.
+ + = 20 mmHg
11
Percentage (95% CI) reduction in incidence
Disease One drug Two drugs Three drugs
Stroke 29 (26 to 31) 49 (42 to 55) 63 (55 to 70)
Ischaemic heart disease events 19 (17 to 21) 34 (29 to 40) 46 (39 to 53)
Effects of blood pressure lowering drugs on reducing the incidence of stroke and ischemic heart disease events when
used separately and in combination at half standard dose*
*Calculated from reductions in blood pressure in table 4 and estimates of association between blood pressure and disease events at
age 60-69 years from the Prospective Studies Collaboration.
BMJ. 2003 ;326:1427
