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EXALT ABPM substudy

Uncontrolled hypertension with SBP>130 mmHg or DBP>80 mmHg* with

any dual therapy of CCBs, ARBs and Diuretics

Moderate doses of ARB/CCB/ diuretic is more effective in

lowering nighttime and daytime ABP

than a maximal dose of an ARB with a diuretic

Change in systolic ABP Change in diastolic ABP

24-h Night time Day time Last 4 h 24 h Night time Day time Last 4 h
mean (10 pm - 6 am) (6 am - 10 pm) dosing mean (10 pm - 6 am) (6 am - 10 pm) dosing
0

Least - squares mean reduction from baseline (mmHg)

-5

-7.4 -7.7
-8.1 -8.6
-10

-13.3 -13.3 -13.0
-15 -13.5

-16.2 -5.27* -5.90* -4.34* -5.82*
-17.4 -17.0

-20 -18.1

-22.0 -22.2 -21.9 -21.5 Valsartan / Amlodipine / HCTZ group (n = 36)

-25 Losartan / HCTZ group (n = 48)
-4.68* -6.05* -3.74 -4.47
A randomized, double-blind, parallel-group study of patients with Stage 2 hypertension. The efficacy variables of this ABPM
substudy were change from baseline in MSSBP and MSDBP at week 6.

Mean reduction in mean ABP at week 6 were significantly greater in the valsartan/amlodipine/HCTZ group than in the losartan/
HCT group (-22.0 ±1.7/-13±1.0 versus -17.4±1.5/ -8.1±0.8 mmHg, P = 0.043/P < 0.001, respectively).
Vasc Health Risk Manag. 2011; 7: 701–708