Page 2 - EUREKA! Summer 2018
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Table of contents




                              3   Understanding and improving medical marijuana

                              5   Social science for seniors


                              6   Getting active in urban nature

                              7   Fine-tuning cancer care


                              8   From the heart: Carleton creativity on display at the Brain
                                  & Mental Health Art Show

                             10   An ounce of prevention: Kristin Connor and Carleton’s Health Sciences
                                  department want to develop “boundary blurring” researchers who can make the
                                  case for early intervention

                             18   The hurt blocker: Mike Hildebrand and his collaborators are doing groundbreaking
                                  experiments to better understand — and alleviate — chronic pain

                            24    Solving the Parkinson’s puzzle: Cross-disciplinary duo from Carleton pioneer
                                  a new approach to stopping the devastating neurodegenerative disease

                                                                                                                                 Suited up to avoid cross-contamination, Carleton Biology professor Shelley Hepworth poses in the “mom” room — a repository for
                            30    A head for holistic health: Health Sciences chair Martin Holcik                                cannabis plant genetics — at Canopy’s production and research facility in the former Hershey’s chocolate factory in Smiths Falls, Ont.
                                                                                                                                 Pending legalization is leading to new research opportunities.
                                                                                                                                 Understanding and improving medical marijuana





                                                                                                                                 By Tyrone Burke                                       headquarters are in the former Hershey’s chocolate factory
        Eureka!                              Giving to Carleton                                                                  Photos by Chris Roussakis                             in Smiths Falls southwest of Ottawa. “They might have
                                             The Faculty of Science at Carleton has many
        Discover Carleton’s Faculty of Science  longstanding partnerships with alumni, friends, the                                                                                    functions in our body. We don’t have that level of detail yet.
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        Editorial advisory board             community and industry who share our vision and                                           ementia, epilepsy, Tourette’s syndrome. Its fiercest   There are many different cannabinoids, and strains with
        Dwight Deugo: Interim Dean, Faculty of Science   provide support in the form of collaboration and                              advocates insist that cannabis will cure whatever ails   particular properties could be good for certain illnesses. We
        Valerie Pereboom: Executive Assistant to the Dean,   financial engagement to help us work toward our goals.
        Faculty of Science                   One of our core values is our commitment to student                                 Dyou, and there’s no shortage of anecdotes to support   could target problems with greater precision.”
        Rima Mattar: Event & Communication Coordinator,   success and academic standards. Our summer research                                                                            Funded by a $50,000 grant from the Ontario Centres
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        Faculty of Science   FSC Label Artwork  internships, scholarships, bursaries and experimental   FSC_Labels_Portrait      these claims. But when it comes to peer-reviewed research,
        Maria DeRosa: Professor, Dept. of Chemistry   funds provide much-needed financial support to science                     facts are harder to come by.                          of Excellence and NSERC, with additional support from
        Andrea Lawrance: Carleton Office for Research   students. We look forward to a future where, with your                                                                         Agriculture Canada, the goal of Hepworth’s project is to
        Initiatives and Services             support, we are the science faculty of choice in Canada                               Cannabis plants have more than 100 cannabinoids. These
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        Mistalyn Seguin: Senior Development Officer,   for students and alumni who value a comprehensive     FSC_Labels_PPBW     chemical compounds influence how messages are sent,   develop polyploid cannabis plants — which contain more
        Dept. of University Advancement      and life-enriching science education. We encourage
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        Fateema Sayani: Content Strategy Specialist,   you to explore the many ways to support the Faculty of   Portrait / Positive / Black & White (PPBW) received and processed by brain cells, and their proportions   than two sets of chromosomes — to increase genetic
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        Dept. of University Advancement      Science with a financial contribution by following us on   On the cover             vary by strain. Recreational cannabis has been bred to have   diversity. “Polyploidization for the Improvement of Medical
        Julie Carl: Research Communications Manager, OVPRI   FutureFunder.ca     Carleton Health Sciences professor
        Ellen Tsaprailis, Dept. of University Communications  Carleton University is fully compliant with FIPPA and   Kristin Connor and two-year-old Sam   high levels of tetrahydrocannabinol (THC), a mind-altering   Cannabis” duplicates cannabis’ chromosomes. It enables
        Editor: Dan Rubinstein, Dept. of University   endeavours at all times to treat your personal information   photographed by Justin Tang in the   psychoactive cannabinoid which can also have health   plants to be bred to have characteristics which could
        Communications            FSC_100_PPC.EPS  in accordance with this law. Personal information is used   atrium of the university’s new Health   FSC_100_PPBW.EPS benefits, such as improving mood and appetite. Medical   otherwise not coexist, and could lead to better medical
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                                                                                 Sciences Building on Thursday, April 19,
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                                                                                 2018. Connor’s research focuses on the
        Communications            FSC_100_PPC.TIF  events and offers from our affinity partners, to   FSC_100_PNC.TIF  FSC_100_PPBW.TIF  marijuana has been bred for its cannabidiol (CBD) content,   cannabis, faster plant growth and novel strains.
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        Contributors: Tyrone Burke, Lisa Gregoire, Blazej Marczak,   communicate Carleton news, and for fundraising   developmental origins of health and   which alleviates symptoms such as pain, inflammation and   “We have strains that are high THC and others that are high
        Joseph Mathieu, Chris Roussakis, Justin Tang  purposes.   Cert no. XXX-XXX-XXX  disease (DOHaD), including an aim to   Cert no. XXX-XXX-XXX  anxiety and can also be desirable in recreational strains,   CBD,” says Hepworth. “If you have high THC, you have low
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                                                                                 understand how preventative medicine
        Eureka! is published for the alumni, faculty, staff, friends   To update your name or address or stop mail, please   and changes to our diets and habits can                   CBD, and vice-versa. It’s an inverse relationship. We are looking
        and partners of the Faculty of Science. The magazine is   contact the Department of University Advancement at   have a positive impact on the health   even if it doesn’t make users high. Other cannabinoids could
        intended to showcase the faculty’s researchers, teachers   1-800-461-8927 or advancement@carleton.ca  of pregnant women and their children.   have additional medical applications.  to more precisely control the ratio and develop better medical
        and students, and to connect alumni to each other                        Sam’s mother, Carleton Biology
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        and the university. It is published in collaboration with           FSC_MS_1_PNC.EPS                         FSC_MS_1_PPBW.EPS “There’s a lot of diversity, and the mechanism of action   strains.” This would allow medical cannabis to simultaneously
                                                                                 professor Jenny Bruin, does research on
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                                                                                 diabetes, with a focus on the influence
        Carleton’s Department of University Communications.                 FSC_MS_1_PNC.JPG                         FSC_MS_1_PPBW.JPG for cannabinoids is still understudied,” says Carleton Biology   induce appetite with THC, for instance, while also alleviating
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                                                                                 of environmental factors on pancreas
        Your input is important                                   FACULTY OF     development and beta cell physiology            professor Shelley Hepworth, who is working on a research   pain with CBD. If applications for other cannabinoids are
        Please send feedback to odscience@carleton.ca or via      Science        — and graciously agreed to let her son                                                                identified, their proportion could be increased.
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        Twitter: @CarletonScience  Cert no. XXX-XXX-XXX           Cert no. XXX-XXX-XXX  steal the show at this photo shoot.  Cert no. XXX-XXX-XXX  project with cannabis giant Canopy Growth Corp., whose
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