Page 6 - EUREKA! Summer 2018
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Image courtesy Dr. James Heilman








                                                                                                                                                                                         Fine-tuning cancer care




                                                                                                                                                                                              bout half of all cancer patients — and 20 percent
                                                                                                                                                                                              of all Canadians — will get radiation therapy as part
                                                                                                                                                                                         Aof their medical care. These statistics, and the fact
                                                                                                                                                                                         that radiation damages healthy cells while destroying
                                                                                                                                                                                         cancer cells, speaks to the need to develop more precise
                                                                                                                                                                                         approaches to cancer treatment. Brachytherapy, which
                                                                                                                                                                                         entails implanting small radioactive sources roughly the
        Go green                                                                                                                                                                         targeted, has been evolving as a technique for more than a
                                                                                                                                                                                         size of a grain of rice (pictured above) near the area being

                                                                                                                                                                                         century, with medical physicists such as Carleton professor
                                                                                                                                                                                         Rowan Thomson working to help refine the treatment.
                                                                                                                                                                                          The standard protocol for brachytherapy begins with
        Gauging the health benefits                                                                                                                                                      deciding where to position the radioactive sources, either
                                                                                                                                                                                         high-dose temporary implants or low-dose and permanent.
                                                                                                                                                                                         Afterward, a CT scan is done to determine the actual
        of getting active in urban nature                                                                                                                                                source locations; this information is used to calculate
                                                                                                                                                                                  Photo: Richard Hinchcliff  of the treatment. Thomson and her collaborators at the
                                                                                                                                                                                         doses, and further analyses evaluates the effectiveness

                                                                                                                                                                                         Ottawa Medical Physics Institute are part of an effort to
                                                                                                                                                                                         come up with more accurate dose calculation algorithms —
                                                                                                                                                                                         using Monte Carlo or probability simulations — and she is
                                                                                                                                                                                         also a member of a task force that’s developing guidelines
                                                                                                                                                                                         for bringing these ideas from the research stage to clinical
                                                                                                                                                                                         practice.
             here is evidence of several health benefits associated   behaviours that increase the risk of chronic disease.”     used Ottawa area bike paths.                             One of Thomson’s current projects revolves around “egs
             with neighbourhood greenness, but reasons for this   The preceding text is taken from a paper published last          “Greenness in urban areas has been linked to a number   brachy,” an open-source code for rapid brachytherapy
        Tare unclear. Studies have found that those who live   year in the journal Environmental Research by Carleton            of healthy behaviours, including reduced obesity and    dose calculations (“egs” is short for electron gamma
        in greener neighbourhoods are more physically active, and   Health Sciences professor Paul Villeneuve, an epidemiologist   increased participation in physical activity, and facilitates   shower) developed at Carleton. It’s currently being tested
        have lower rates of obesity. Relatively few studies have   and biostatistician cross-appointed to the School of          social interaction that come with its own health benefits,”   on 40 patients in Kelowna, B.C., where brachytherapy is
        attempted to characterize associations between greenness   Mathematics and Statistics. Villeneuve and his students have   Villeneuve wrote in an email to the Ottawa Citizen.    common because many cancer patients in the region live
        and both obesity and physical activity concurrently, or   also done research showing that the four square kilometres     “Greenness in urban areas has also been linked to a     in remote locations and cannot easily come to the city
        among women who are at higher risk of developing cancer   of green space in Ottawa’s Central Experiment Farm —           number of important health outcomes including improved   for treatment. “Medical doctors prescribe radiation as
        and for whom physical activity may be important for    where the accompanying photo was taken — improves air             sleep quality, reduced stress and lower mortality. These   a treatment,” says Thomson, Canada Research Chair in
        primary prevention…. Our findings indicate that, amongst   quality, reduces pollution and lowers temperatures in the     effects have been observed in both affluent and low-    Radiotherapy Physics, “and medical physicists study the
        U.S. adult women at higher risks of breast cancer, residential   surrounding area. This summer, they will begin mapping air   income neighbourhoods.”                            interaction of radiation and matter so we can improve the
        proximity to greenness may help mitigate against sedentary   pollution, noise and temperature measures along commonly                                                            care patients receive.”



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