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International Conference on

Recent Trends in Environmental Sustainability

ESCON22/FWSH/24
Synthesis of heterocycle bicycle organic compounds through electrochemical process

*1
Zia Ul Haq Khan
1 Department of Environmental Sciences COMSATS University Islamabad, Vehari Campus

Correspondence: ziakhan@ciitvehari.edu.pk
Abstract

Electrochemistry plays important role in organic synthesis in laboratories as well as in
industrial level. The transfer of electrons is one of the most important processes in organic
chemistry and most of the organic reactions are take place through transfer of electrons. The
process is always reversible only in the condition, when the creative intermediate is stable
under the experimental condition. During EC process most of the inactive organic substrate
reacts without the use of external catalyst, but the current also act as a catalyst. In
electrochemical redox reaction, electron transfer and electron acceptance are take place in same
solution, due to which bond formation and dissociation are take place. The EC method play
important role in the carbon-carbon bond formation and transformation of one functional group
to other. For the formation of carbon-carbon bond, Kolbe reaction is the most authentic
example, which involves the anodic oxidation of carboxylate ions. Different type of techniques
like polarography, cyclic voltammetric and linear sweep voltammetry can be used to determine
the electrochemical reaction pathway. In modern organic synthesis, low temperatures are often
employed to conduct reactions in a highly selective manner. However, it has been considered
that electrochemical reactions should be conducted at around room temperature and that the
presence of moisture is inevitable, although this is not the case anymore if we choose an
appropriate solvent/electrolyte system. Such issues might be a barrier to applications of the
electrochemical method in organic synthesis. Pyrimidines are an important class of
heterocyclic compounds. Hetero-cycles containing pyrimidine moiety are of great interest
because they constitute an important class of natural and non-natural products, many of which
exhibit useful biological activities and clinical applications. The pyrimidines represent one of
the most active classes of compounds possessing wide spectrum of biological activities like
significant in vitro activity against unrelated DNA and RNA, viruses including polioherpes
viruses, diuretic, anti-tumour, anti-HIV, and cardiovascular. In addition to this, various analogs
of pyrimidines have been found to possess antibacterial, antifungal, anti-leishmanial, anti-
inflammatory, analgesic, antihypertensive, antipyretic, antiviral, anti-diabetic, anti-allerggic,
anticonvulsant, antioxidant antihistaminic, herbicidal and anticancer activities and many of
pyrimidine’s derivatives are reported to possess potential central nervous system (CNS)
depressant properties and also act as calcium channel blockers. The demand of the
pyrimidine’s derivatives is increasing day by day. In order to fulfill the requirement, we are
interesting to introduce EC techniques for the synthesis of the new pyrimidines’ derivatives.
Keywords: Electrochemical Process; DNA; RNA; CNS

Department of Environmental Sciences, COMSATS University Islamabad, Vehari Campus

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