Page 16 - Cleaning and sanitation in GMP
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GMP Training – Cleaning and Sanitation in GMP Areas by www.gmpsop.com
These operators are preparing to dean a
dispensary used to weigh out powders.
They are wearing hair nets.
They are wearing protective gloves and
face masks.
They are wearing disposable gowns.
They are checking the procedure to verify
if the chemical residues may need special
handling.
While your company may not use all these
specific precautions, it's important to ensure
you follow the written procedure and protect
yourself when cleaning.
Most production facilities are multi-use, that is, on any given day, different
products will be simultaneously processed, but never in the same rooms. The
primary means of preventing cross-contamination in multi-use facilities are the
air controls (sometimes called HVAC).
Room pressures serve a couple of functions. They contain dust within a room,
and prevent the dust from getting into other rooms (negative pressure). Room
pressures also exclude outside air containing dust, dirt and microbial particles
from entering a facility (positive pressure). If these pressures are lost, then there
is potential risk of contamination. No amount of laboratory testing could
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