Page 226 - Physiology and Pathophysiology MNU 2024-2025 نظرى

Clinical pharmacy 2024/2025 Level 2 Pharm D Physiology and Pathophysiology (MD303)
Male Reproductive Physiology

• The male gonads, testis, secrets androgenic hormones, mainly Testosterone.

Through Hypothalamic–Pituitary–Testicular Axis

Testis

♠ The testis contains.
a) Leydig cells that produce testosterone.

b) Blood vessels
c) Seminiferous tubules ➔ produce sperm and house Sertoli cells.
► The testicular endocrine functions reside in Leydig cells and Sertoli cells ➔which

work to synthesize testosterone and, to a lesser extent, estradiol.

Leydig cells Sertoli cells
secretes testosterone in ✓ (In response to FSH) convert a small fraction of
response to LH. testosterone into estradiol.

Testosterone diffuses to ✓ secrete androgen binding protein (ABP) along with
Sertoli cells testosterone into the seminiferous tubular lumen

Spermatogenesis:

Definition regulated by
✓ The development of spermatogonia into 1ry ✓ testosterone, and
spermatocytes; 2ry spermatocytes; testosterone level is

spermatids; and, finally, into spermatozoa. maintained by ABP.

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