Page 105 - pharma 1 theoretical updated MNU_Neat

Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

NOTE
➢ Digitalis or digitalis glycosides ➔ come from the digitalis (foxglove) plant [The most

widely used agent is digoxin]
➢ influence sodium and calcium ion flows in the cardiac muscle ➔ ↑contraction of the
atrial and ventricular myocardium (positive inotropic action)

➢ Digitalis glycosides show only a small difference between a therapeutically effective
dose and doses that are toxic or even fatal.
➢ Therefore, the drugs have a low therapeutic index

1- Severe left ventricular systolic dysfunction after initiation of ACE
inhibitor and diuretic therapy.
 mild to moderate HF will often respond to treatment with ACE

Therapeutic uses inhibitors, diuretics ➔not require digoxin.
 Digoxin is not indicated in patients with diastolic or right-
sided HF (pulmonary edema)

2- major indication is HF with atrial fibrillation.

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