Page 119 - pharma 1 theoretical updated MNU_Neat

Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

Notes
 These transient episodes (15 seconds to 15 minutes) of myocardial ischemia do not
cause cellular death such as occurs in myocardial infarction.

 Chronic ischemia may lead to deterioration of cardiac function, leading, in turn, to

heart failure, arrhythmias, and sudden death.

 It is caused by the reduction of coronary perfusion due to a fixed obstruction of a
coronary artery produced by atherosclerosis.

 Due to the fixed obstruction →blood supply cannot increase →heart becomes

vulnerable to ischemia whenever there is increased demand, such as that produced by
physical activity, emotional excitement, or any other cause of increased cardiac
workload.

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