Page 19 - pharma 1 theoretical updated MNU_Neat

Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

Adrenergic transmission

Adrenergic or sympathomimetic drugs

 drugs which imitate or produce the same effects as the stimulation of the sympathetic
nervous system.
Classification of Sympathomimetic:

1. Direct acting sympathomimetics → norepinephrine,

epinephrine, isoproterenol, and dopamine
According to 2. Indirect acting sympathomimetics → Act by causing release

mechanism of of NE from adrenergic neurons

action  amphetamine and tyramine
3. Dual effect: → By both direct and indirect effect

 ephedrine

Classified 1) Catecholamines → contains the catechol nucleus 
epinephrine, norepinephrine and isoproterenol.
chemically
2) Non-catecholamines → amphetamine, ephedrine and tyramine

According to 1. Natural → norepinephrine, epinephrine and dopamine
2. Synthetic → isoproterenol, amphetamine, tyramine and
origin
ephedrine

| P a g e - 3 -