Page 21 - pharma 1 theoretical updated MNU_Neat

Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

Drugs that Interference with adrenergic mechanisms:

Drug may mimic or impair adrenergic mechanisms through:

E (agonist) or
1. Directly ➔ by binding to receptor
propranolol (antagonist).
amphetamine. &
2. Indirectly ➔ by releasing NE stored in nerve endings
tyramine
preventing reuptake of released NE into adrenergic cocaine, tricyclic
3.
nerve ending antidepressants.

4. preventing destruction of NE in nerve ending MAOIs.
5. depleting stores of NE in nerve endings reserpine.
preventing release of NE from nerve endings in
6. guanethidine.
response to a nerve impulse
activation of 2 receptors on nerve endings➔ inhibit
7. clonidine.
release of NE
8. blocking sympathetic ganglia trimethaphan

| P a g e - 5 -