Page 196 - pharma 1 theoretical updated MNU_Neat

Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)
NB

 Typical iron deficit is between 500-1000 mg
 A fixed dose of ~ 1000 mg ➔ sufficient to treat anemia and provide additional

storage iron without causing iron overload → administered as a single dose (TDI) or
as multiple infusions depending on the iron product used (e.g. 10 doses × 100 mg of
LMW-ID).

 Vitamin B12 deficiency Anemia

➢ IM or SC: 1 mg/day for 1 week ➔ 1 mg/week
➢ Followed by for 1 month or until the Hb normalizes.
Vitamin B12 ➢ Life-long maintenance therapy (1 mg/month) → for patients with
administration pernicious anemia or surgical resection of the terminal ileum.
protocol ➢ A common oral dosing regimen is 1-2 mg/day.

➢ Oral vitamin B12 can be used as maintenance therapy after
parenteral administration.

 Folic Acid deficiency Anemia

➢ 1 mg/day, orally → rapid and complete absorption.
The effective dose ➢ Patients with malabsorption syndromes may require oral doses
of folic acid
up to 5 mg/day.

occurs within days of starting therapy
Resolution of Typically, a patient’s Hgb will start to rise after 2 weeks of therapy
symptoms
and normalize after 2 to 4 months of therapy

Evaluation of Re-evaluate patients who fail to normalize Hgb levels after 2
outcome months of therapy.

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