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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)
K sparing diuretics (overcome K loss)
+
+
Epithelial sodium channel
Class Aldosterone receptor antagonists
blockers
Ex. Amiloride & Triamterene Spironolactone & Eplerenone
➢ Inhibit Na transport at late Aldosterone receptor antagonist ➔
+
+
MOA Distal &collecting duct K loss in urine
+
+
-
+
➢ Act on Na /Cl transport affect regulation of Na and K
➢ Prevent hypokalemia in the same manner
as Amiloride.
➢ additional benefit of diminishing cardiac
remodeling that occurs in congestive heart
➢ Prevention & treatment of
Uses hypokalemia induced by failure
thiazide & loop diuretics. ➢ Treatment of primary hyperaldosteronism
& edema of liver cirrhosis.
➢ Because of its anti-androgenic effect ➔
used in ttt of polycystic ovary disease &
hirsutism in women.
➢ Gynecomastia & impotence in men &
Hyperkalemia ➔ unlikely
to occur unless the patient: menstrual irregularities in female
1- Ingests K supplements or patients (caused by the drug's anti-
androgenic effects)
ADR other drugs that serum K ➢ Hyperkalemia.
levels +
2- patient has a renal disorder Eplerenone ➔ K sparing diuretic
(analogue of spironolactone) with no
that cause hyperkalemia.
antiandrogen S/E ➔ used in Heart failure
is most effectively employed in mild edematous state for which is given for
Note few days (not used for long time)
At low dose it can be used chronically with few S/E
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