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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

 Carbonic anhydrase inhibitors
e.g. Acetazolamide (oral), Dorzolamide & Brinzolamide (topical)

 Inhibit CA (Carbonic anhydrase) throughout the body.
MOA  CO2 + H2O  HCO3 + H (hydrogen acid)
+
-
 So  formation of aqueous humor ➔  IOP ➔ treats glaucoma.

Treatment of disorders such as:
Uses  High-altitude sickness ( aqueous fluid from the ears).

 Glaucoma.
1) Acetazolamide  the excretion of weak bases such as amphetamine,
ephedrine & quinidine ➔ their serum levels ➔ drug toxicity.
S/E Because it causes alkaline urine.

2) Hypokalemia
3) Hyperglycemia.

Note Dorzolamide & Brinzolamide combined with Timolol to treat glaucoma

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