Page 69 - pharma 1 theoretical updated MNU_Neat

Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

 Thiazide like diuretics

Chlorthalidone DOA ➔ once daily ➔ Patient compliance.

✓ effective in patients with renal dysfunction

Metolazone ✓ More potent than Thiazide
+
✓ unlike thiazides cause to Na excretion in advanced renal
failure.
✓ Lipid soluble ➔ DOA with Low dose has significant

antihypertensive effect with minimal diuretic effect.

Indapamide (frequency of urination) ➔ used with elderly
✓ Metabolized and excreted by GIT & kidney ➔ less like to

accumulated in patients with renal failure ➔Useful in their
treatment

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