Page 65 - phytochemistry general program
P. 65
Me -
nBut Br
+
N
O
H
H OH
O
O
Hyoscine butylbromide
Uses
It is used for the treatment of gastrointestinal spasm, hypermotility, post-
operative vomiting, spastic constipation and spasm of the urinary tract.
Pharmacology and precautions of solanaceous tropane alkaloids
Atropine, hyoscyamine and scopolamine are anti-cholinergic agents. .1
They Increase heart rate (by depression of the vagus nerve) so they are .2
contra-indicated in patients suffering from hypertension. Also not preferably
concomitantly taken with Anti-cholinergics, sympathomimetics (ex: anti- .3
.4
depressents)
Act as antispasmodic on various smooth muscles (ureter, bladder and
intestine) thus, are contra-indicated in patients with benign prostatic
hypertrophy and paralytic ileus.
They cause mydriasis, so contra-indicated in acute glaucoma.
Identification of solanaceous tropane alkaloid
1- Vitali-Morine's test
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