Page 61 - phytochemistry general program
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The optically inactive (racemic mixture) dl-form occurs in atropine. .2
2- Atropic acid in apoatropine.
COOH COOH
C CH2O H C CH2O H
H H
(-) - Tropic acid (+) - T ropic acid
COOH
Atropic acid
Atropine .1
Occurrence
Atropine is obtained from Atropa belladonna, Hyoscyamus, Datura and
Duboisia species.
Me
N
H OH
H
O
O
Atropine (dl (±) hyoscyamine)
Properties
It is the racemic form (dl-mixture) of hyoscyamine, so it is optically inactive
(consisting of equimolar mixture of d-tropic & l-tropic esters). It is formed from
hyoscyamine during the process of extraction.
Atropine is readily hydrolysed by treatment with alkali or dilute acid yielding
tropic acid and tropine. Atropine SO4 is the most commonly used form among its
salts for medicinal purposes.
Uses
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